6,8-二溴咪唑并[1,2-a]吡嗪-2-羧酸乙酯合成路线 （共 3 条）
反应条件
in carbonic acid dimethyl ester
T=20 - 110°C;
参考文献
BAYER PHARMA AKTIENGESELLSCHAFT; KOPPITZ, Marcus; KLAR, Ulrich; JAUTELAT, Rolf; KOSEMUND, Dirk; BOHLMANN, Rolf; BADER, Benjamin; LIENAU, Philip; SIEMEISTER, Gerhard
Patent: WO2012/80234 A1, 2012 ;
Location in patent: Page/Page column 45 ;
WO 2012/080234 A1
反应条件
1.) DMC, reflux, 3 h, 2.) EtOH, reflux, 1 h; Yield given. Multistep reaction;
参考文献
Sablayrolles; Cros; Milhavet; Rechenq; Chapat; Boucard; Serrano; McNeill
Journal of Medicinal Chemistry, 1984 , vol. 27, # 2 p. 206 - 212
反应条件
ammonium hydroxide
T=20°C; Substitution; 4 h;
参考文献
Vitse, Olivier; Laurent, Florence; Pocock, Tristan M.; Benezech, Veronique; Zanik, Lahcen; Elliott, Keith R. F.; Subra, Guy; Portet, Karine; Bompart, Jacques; Chapat, Jean-Pierre; Small, Roger C.; Michel, Alain; Bonnet, Pierre-Antoine
Bioorganic and Medicinal Chemistry, 1999 , vol. 7, # 6 p. 1059 - 1065
