4-羟基-3-甲基苯乙酮合成路线 （共 45 条）
反应条件
T=40°C; Product distribution;
参考文献
Journal of the Chemical Society, , p. 3894
反应条件
T=40°C; Product distribution;
参考文献
Journal of the Chemical Society, , p. 3894
反应条件
potassium carbonate in acetone 24 h; Reflux;
参考文献
Buckman, Brad Owen; Nicholas, John Beamond; Ramphal, Johnnie Y.; Emayan, Kumaraswamy; Seiwert, Scott D.
Patent: US2014/94456 A1, 2014 ;
Location in patent: Paragraph 1024-1025 ;
反应条件
1: 99 percent / Cs2CO3 / acetonitrile / 16 h / 20 °C 2: 87 percent / m-chloroperbenzoic acid; p-TsOH / CH2Cl2 / 6 h / Heating 3: NaOCH3; MeOH 4: 100 percent / DMAP; Et3N / dioxane / 16 h / Heating 5: 47 percent / various solvent(s) / 253 °C 6: 34 percent / NaOCH3; MeOH / 16 h / 70 °C 7: Cs2CO3 / acetonitrile / 16 h / 20 °C 8: 1 N aq. LiOH / tetrahydrofuran View Scheme
参考文献
Sznaidman, Marcos L.; Haffner, Curt D.; Maloney, Patrick R.; Fivush, Adam; Chao, Esther; Goreham, Donna; Sierra, Michael L.; LeGrumelec, Christelle; Xu, H. Eric; Montana, Valerie G.; Lambert, Millard H.; Willson, Timothy M.; Oliver Jr., William R.; Sternbach, Daniel D.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 9 p. 1517 - 1521
反应条件
1: Cs2CO3 / acetonitrile / 20 °C 2: meta-chloroperbenzoic acid; p-TsOH / CH2Cl2 / 48 h / Heating 3: MeONa / methanol / 1 h / 20 °C View Scheme
参考文献
Novo Nordisk A/S; High Point Phamaceticals LLC
Patent: US2011/39841 A1, 2011 ;
US 20110039841 A1
反应条件
1: 99 percent / Cs2CO3 / acetonitrile / 16 h / 20 °C 2: 87 percent / m-chloroperbenzoic acid; p-TsOH / CH2Cl2 / 6 h / Heating 3: NaOCH3; MeOH 4: 100 percent / DMAP; Et3N / dioxane / 16 h / Heating 5: 47 percent / various solvent(s) / 253 °C 6: 34 percent / NaOCH3; MeOH / 16 h / 70 °C 7: Cs2CO3 / acetonitrile / 16 h / 20 °C View Scheme
参考文献
Sznaidman, Marcos L.; Haffner, Curt D.; Maloney, Patrick R.; Fivush, Adam; Chao, Esther; Goreham, Donna; Sierra, Michael L.; LeGrumelec, Christelle; Xu, H. Eric; Montana, Valerie G.; Lambert, Millard H.; Willson, Timothy M.; Oliver Jr., William R.; Sternbach, Daniel D.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 9 p. 1517 - 1521
反应条件
1: iodine 2: aq. NaOH solution; aq.-ethanolic NaOH-solution View Scheme
参考文献
King; McWhirter; Barton
Journal of the American Chemical Society, 1945 , vol. 67, p. 2089,2090
反应条件
hydrogen; palladium(II) hydroxide/carbon in acetic acid T=25°C; P=3102.97 Torr; 16 h;
参考文献
Wang, Jane L.; Aston, Karl; Limburg, David; Ludwig, Cindy; Hallinan, Ann E.; Koszyk, Francis; Hamper, Bruce; Brown, David; Graneto, Matthew; Talley, John; Maziasz, Timothy; Masferrer, Jaime; Carter, Jeffery
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 23 p. 7164 - 7168
反应条件
(i) sulfur, Mor, (ii) aq. NaOH; Multistep reaction;
参考文献
ICI
Patent: DE2007751 , 1970 ;
Chem.Abstr., 1970 , vol. 73, # 120318
参考文献
Wittig; Schulze
Journal fuer Praktische Chemie (Leipzig), 1931 , vol. <2> 130, p. 81,90
