4-羟基-3-甲基苯乙酮合成路线 （共 45 条）
参考文献
King; McWhirter; Barton
Journal of the American Chemical Society, 1945 , vol. 67, p. 2089,2090
参考文献
King; McWhirter; Barton
Journal of the American Chemical Society, 1945 , vol. 67, p. 2089,2090
参考文献
NPS Pharmaceuticals, Inc.; The Brigham and Women's Hospital
Patent: US6011068 A1, 2000 ;
US 6011068 A
反应条件
1: potassium carbonate / acetonitrile / 8 h / 20 °C
2: 3-chloro-benzenecarboperoxoic acid / toluene-4-sulfonic acid / dichloromethane / 20 °C
3: ethanol / toluene-4-sulfonic acid / 6 h / Reflux
View Scheme
参考文献
Zhejiang Hisun Pharmaceutical Co., Ltd.
Patent: US2011/319458 A1, 2011 ;
US 20110319458 A1
反应条件
1: 99 percent / Cs2CO3 / acetonitrile / 16 h / 20 °C
2: 87 percent / m-chloroperbenzoic acid; p-TsOH / CH2Cl2 / 6 h / Heating
3: NaOCH3; MeOH
4: 100 percent / DMAP; Et3N / dioxane / 16 h / Heating
5: 47 percent / various solvent(s) / 253 °C
6: 34 percent / NaOCH3; MeOH / 16 h / 70 °C
View Scheme
参考文献
Sznaidman, Marcos L.; Haffner, Curt D.; Maloney, Patrick R.; Fivush, Adam; Chao, Esther; Goreham, Donna; Sierra, Michael L.; LeGrumelec, Christelle; Xu, H. Eric; Montana, Valerie G.; Lambert, Millard H.; Willson, Timothy M.; Oliver Jr., William R.; Sternbach, Daniel D.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 9 p. 1517 - 1521
