(4-环丙基磺酰基苯基)氧代乙酸乙酯合成路线 （共 4 条）
反应条件
3-chloro-benzenecarboperoxoic acid in dichloromethane
T=5 - 20°C; 2 h;
参考文献
Dunlap, Jeanette Tower; Stephenson, Gregory Alan
Patent: US2009/181981 A1, 2009 ;
Location in patent: Page/Page column 4; 5 ;
反应条件
1.1: AlCl3, aluminium chloride / dichloromethane / 0.75 h / 0 °C / Inert atmosphere
1.2: 2 h / 25 °C
2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 4 h / 0 - 25 °C
View Scheme
参考文献
Advinus Therapeutics Private Limited
Patent: EP2402327 A1, 2012 ;
反应条件
1: 4-THP-CH2PPh3I With lithium hexamethyldisilazane in tetrahydrofuran
T=-5 - 15°C; 2.5 h;
2: ethyl (4-cyclopropylsulfonylphenyl)oxoacetate in tetrahydrofuran
T=0 - 25°C; 17 h;
3: With hydrogenchloride; methanol; sodium hydroxide; water
more than 3 stages;
参考文献
PROSIDION LIMITED
Patent: WO2006/16178 A1, 2006 ;
Location in patent: Page/Page column 12-13 ;
反应条件
1: 4-THP-CH2PPh3I With lithium hexamethyldisilazane in tetrahydrofuran
T=-5 - 15°C; 2.5 h;
2: ethyl (4-cyclopropylsulfonylphenyl)oxoacetate in tetrahydrofuran
T=0 - 25°C; 17 h;
3: With hydrogenchloride; methanol; sodium hydroxide; water
more than 3 stages;
参考文献
PROSIDION LIMITED
Patent: WO2006/16174 A1, 2006 ;
Location in patent: Page/Page column 15 ;
WO 2006/016174 A1
