3,7-二甲基-4,6-二丙基吡啶并[3,2-g]喹啉-2,5,8,10(1H,9H)-四酮合成路线 （共 21 条）
反应条件
1: in trifluoroacetic acid
T=20°C; Oxidation; 4 h;
2: With p-toluenesulfonyl chloride in water; acetonitrile
T=60°C; Rearrangement; 4 h;
参考文献
Perez, Jose Maria; Lopez-Alvarado, Pilar; Pascual-Alfonso, Eva; Avendano, Carmen; Menendez, J. Carlos
Tetrahedron, 2000 , vol. 56, # 26 p. 4575 - 4583
反应条件
hydrogenchloride
T=11°C; 1.5 h;
参考文献
Kelly, T. Ross; Field, Jeffrey, A.; Li, Qun
Tetrahedron Letters, 1988 , vol. 29, # 29 p. 3545 - 3546
反应条件
p-toluenesulfonyl chloride in water; acetonitrile
T=60°C; 24 h; Yield given;
参考文献
Perez, Jose Maria; Lopez-Alvarado, Pilar; Avendano, Carmen; Menendez, J. Carlos
Tetrahedron Letters, 1998 , vol. 39, # 7 p. 673 - 676
反应条件
1: 82 percent / N,N-diisopropylethylamine / tetrahydrofuran / 1.) 0 deg C 30 min; 2.) reflux 12.5 h
2: 100 percent / H2 / Raney Ni / ethyl acetate / 3.5 h / 20 °C / 912 Torr
3: 92 percent / 0.67 h / Heating
4: 81 percent / 1 N HCl / acetone; tetrahydrofuran / 23 h / 65 °C
5: 95 percent / cc. HCl / 1.5 h / 11 °C
View Scheme
参考文献
Kelly, T. Ross; Field, Jeffrey, A.; Li, Qun
Tetrahedron Letters, 1988 , vol. 29, # 29 p. 3545 - 3546
反应条件
1: 100 percent / H2 / Raney Ni / ethyl acetate / 3.5 h / 20 °C / 912 Torr
2: 92 percent / 0.67 h / Heating
3: 81 percent / 1 N HCl / acetone; tetrahydrofuran / 23 h / 65 °C
4: 95 percent / cc. HCl / 1.5 h / 11 °C
View Scheme
参考文献
Kelly, T. Ross; Field, Jeffrey, A.; Li, Qun
Tetrahedron Letters, 1988 , vol. 29, # 29 p. 3545 - 3546
反应条件
1.1: 14 percent / silica gel / CHCl3 / 0.02 h / 20 °C
2.1: UHP / trifluoroacetic acid / 4 h / 20 °C
2.2: 30 percent / TsCl / acetonitrile; H2O / 4 h / 60 °C
View Scheme
参考文献
Perez, Jose Maria; Lopez-Alvarado, Pilar; Pascual-Alfonso, Eva; Avendano, Carmen; Menendez, J. Carlos
Tetrahedron, 2000 , vol. 56, # 26 p. 4575 - 4583
反应条件
1: 95 percent / glac. AcOH / diethyl ether / 0.5 h / 45 °C
2: 99 percent / Et3N / CHCl3 / 0.02 h / 20 °C
3: 73 percent / UHP / trifluoroacetic acid / 0.17 h / 20 °C
4: UHP / trifluoroacetic acid / 24 h / 20 °C
5: 43 mg / TsCl / acetonitrile; H2O / 24 h / 60 °C
View Scheme
参考文献
Perez, Jose Maria; Lopez-Alvarado, Pilar; Pascual-Alfonso, Eva; Avendano, Carmen; Menendez, J. Carlos
Tetrahedron, 2000 , vol. 56, # 26 p. 4575 - 4583
反应条件
1: UHP / trifluoroacetic acid / 24 h / 20 °C
2: 43 mg / TsCl / acetonitrile; H2O / 24 h / 60 °C
View Scheme
参考文献
Perez, Jose Maria; Lopez-Alvarado, Pilar; Pascual-Alfonso, Eva; Avendano, Carmen; Menendez, J. Carlos
Tetrahedron, 2000 , vol. 56, # 26 p. 4575 - 4583
反应条件
1: 99 percent / Et3N / CHCl3 / 0.02 h / 20 °C
2: 73 percent / UHP / trifluoroacetic acid / 0.17 h / 20 °C
3: UHP / trifluoroacetic acid / 24 h / 20 °C
4: 43 mg / TsCl / acetonitrile; H2O / 24 h / 60 °C
View Scheme
参考文献
Perez, Jose Maria; Lopez-Alvarado, Pilar; Pascual-Alfonso, Eva; Avendano, Carmen; Menendez, J. Carlos
Tetrahedron, 2000 , vol. 56, # 26 p. 4575 - 4583
反应条件
1.1: 65 percent / MnO2 / CH2Cl2 / 0.5 h / 20 °C
2.1: UHP / trifluoroacetic acid / 4 h / 20 °C
2.2: 30 percent / TsCl / acetonitrile; H2O / 4 h / 60 °C
View Scheme
参考文献
Perez, Jose Maria; Lopez-Alvarado, Pilar; Pascual-Alfonso, Eva; Avendano, Carmen; Menendez, J. Carlos
Tetrahedron, 2000 , vol. 56, # 26 p. 4575 - 4583
