3-溴-1-(三异丙基硅基)吡咯合成路线 （共 23 条）
反应条件
N-bromosuccinmide; hydroquinone in acetone 1 h; Heating;
参考文献
Stefan, Klaus-Peter; Schuhmann, Wolfgang; Parlar, Harun; Korte, Friedhelm
Chemische Berichte, 1989 , vol. 122, p. 169 - 174
反应条件
1: tetrahydrofuran 2: N-bromosuccinimide / acetonitrile View Scheme
参考文献
Angewandte Chemie - International Edition, , vol. 45, # 21 p. 3484 - 3488
反应条件
1: With N-bromosuccinmide in tetrahydrofuran T=-80 - 20°C; 2 h; 2: With pyridine in tetrahydrofuran; hexane 1 h;
参考文献
Chemistry - A European Journal, , vol. 10, # 24 p. 6497 - 6509
反应条件
N-bromosuccinmide in tetrahydrofuran; water
反应条件
dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; triethylamine; dichloro bis(acetonitrile) palladium(II) in toluene T=90°C; 18 h;
参考文献
Billingsley, Kelvin; Buchwald, Stephen L.
Journal of the American Chemical Society, 2007 , vol. 129, # 11 p. 3358 - 3366
反应条件
CH3CH2CH2CH2Li in tetrahydrofuran treatment of pyrrole deriv. with butyllithium in THF at -78°C, addn. of borolane deriv.;
参考文献
Ayats, Carles; Soley, Roger; Albericio, Fernando; Alvarez, Mercedes
Organic and Biomolecular Chemistry, 2009 , vol. 7, # 5 p. 860 - 862
反应条件
tetrabutyl ammonium fluoride in tetrahydrofuran 0.0833333 h; Ambient temperature;
参考文献
Bray, Brian L.; Mathies, Peter H.; Naef, Reto; Solas, Dennis R.; Tidwell, Thomas T.; et al.
Journal of Organic Chemistry, 1990 , vol. 55, # 26 p. 6317 - 6328
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Muchowski, Joseph M.; Solas, Dennis R.
Tetrahedron Letters, 1983 , vol. 24, # 33 p. 3455 - 3456
反应条件
1: 3-bromo-1-(triisopropylsilyl)pyrrole With tert.-butyl lithium in tetrahydrofuran; pentane T=-78°C; Metallation; 0.333333 h; 2: tert-nitrodienamine in tetrahydrofuran T=-78 - 20°C; Alkylation;
参考文献
Heterocycles, , vol. 53, # 6 p. 1351 - 1359
反应条件
1: With tert.-butyl lithium in tetrahydrofuran T=-80°C; 0.166667 h; Schlenk techniqueInert atmosphere; 2: With methanol in tetrahydrofuran T=-75°C; Inert atmosphereSchlenk technique;
参考文献
Waldmann, Christopher; Schober, Otmar; Haufe, Guenter; Kopka, Klaus
Organic Letters, 2013 , vol. 15, # 12 p. 2954 - 2957
反应条件
n-butyllithium; tetrabutyl ammonium fluoride 1.) THF, hexane, -23 deg C, 2 h, 2.) THF; Multistep reaction;
参考文献
Kozikowski, Alan P.; Cheng, Xue-Min
Journal of Organic Chemistry, 1984 , vol. 49, # 17 p. 3239 - 3240
