5-溴-4-氯-7-氮杂吲哚合成路线 （共 5 条）
反应条件
tetrabutyl ammonium fluoride in tetrahydrofuran T=20°C; 1 h;
参考文献
ARRAY BIOPHARMA INC.
Patent: WO2009/89352 A1, 2009 ;
Location in patent: Page/Page column 59 ;
WO 2009/089352 A1
反应条件
1.1: 3-chloro-benzenecarboperoxoic acid / hexane; ethylene glycol dimethyl ether / 3 h / 20 °C 2.1: methanesulfonyl chloride / N,N-dimethyl-formamide / 2 h / 70 °C 3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C / |Inert atmosphere 3.2: 50 °C / |Inert atmosphere 4.1: sec.-butyllithium / tetrahydrofuran; cyclohexane / 0.5 h / 78 °C / |Inert atmosphere 4.2: 2 h 5.1: potassium fluoride / methanol / 1 h / 20 °C View Scheme
参考文献
ChemMedChem, , vol. 9, # 2 p. 277 - 281
反应条件
1.1: methanesulfonyl chloride / N,N-dimethyl-formamide / 2 h / 70 °C 2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C / |Inert atmosphere 2.2: 50 °C / |Inert atmosphere 3.1: sec.-butyllithium / tetrahydrofuran; cyclohexane / 0.5 h / 78 °C / |Inert atmosphere 3.2: 2 h 4.1: potassium fluoride / methanol / 1 h / 20 °C View Scheme
参考文献
ChemMedChem, , vol. 9, # 2 p. 277 - 281
反应条件
1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C / |Inert atmosphere 1.2: 50 °C / |Inert atmosphere 2.1: sec.-butyllithium / tetrahydrofuran; cyclohexane / 0.5 h / 78 °C / |Inert atmosphere 2.2: 2 h 3.1: potassium fluoride / methanol / 1 h / 20 °C View Scheme
参考文献
ChemMedChem, , vol. 9, # 2 p. 277 - 281
反应条件
1.1: sec.-butyllithium / tetrahydrofuran; cyclohexane / 0.5 h / 78 °C / |Inert atmosphere 1.2: 2 h 2.1: potassium fluoride / methanol / 1 h / 20 °C View Scheme
参考文献
ChemMedChem, , vol. 9, # 2 p. 277 - 281
