5-溴-4-氯-2-碘-1H-吡咯并[2,3-b]吡啶合成路线 （共 2 条）
反应条件
1: With sodium hydroxide in tetrahydrofuran; methanol
T=20°C; 0.5 h;
2: With ammonium chloride; water in tetrahydrofuran; methanol
参考文献
Dong, Han-Qing; Foreman, Kenneth; Li, An-Hu; Mulvihill, Mark Joseph; Panicker, Bijoy; Steinig, Arno G.; Stolz, Kathryn M.; Weng, Qinghua; Jin, Meizhong; Volk, Brian; Wang, Jing; Wang, Ti; Beard, James D.
Patent: US2007/129364 A1, 2007 ;
Location in patent: Page/Page column 79 ;
US 20070129364 A1
反应条件
potassium carbonate; bis-triphenylphosphine-palladium(II) chloride in 1,4-dioxane; water
5 h; Heating / reflux;
参考文献
Dong, Han-Qing; Foreman, Kenneth; Li, An-Hu; Mulvihill, Mark Joseph; Panicker, Bijoy; Steinig, Arno G.; Stolz, Kathryn M.; Weng, Qinghua; Jin, Meizhong; Volk, Brian; Wang, Jing; Wang, Ti; Beard, James D.
Patent: US2007/129364 A1, 2007 ;
Location in patent: Page/Page column 78 ;
US 20070129364 A1
