(3S)-3-[(叔丁氧羰基)氨基]哌啶-1-羧酸苄酯合成路线 （共 2 条）
反应条件
1.1: sodium hydride / N,N-dimethyl-formamide; paraffin oil (nujol) / 0 °C 1.2: 4 h / 20 °C 2.1: hydrogen / palladium 10 on activated carbon / methanol / 2 h View Scheme
参考文献
BIOGEN IDEC MA INC.; SUNESIS PHARMACEUTICALS, INC.; HOPKINS, Brian, T.; SCOTT, Daniel; CONLON, Patrick; JENKINS, Tracy, J.; POWELL, Noel; GUAN, Bing; CURERVO, Julio, H.; WANG, Deping; TAVERAS, Art
Patent: WO2012/58645 A1, 2012 ;
WO 2012/058645 A1
反应条件
hydrogenchloride in 1,4-dioxane T=20°C; 1 h;
参考文献
Hennessy, Edward J.; Saeh, Jamal C.; Sha, Li; MacIntyre, Terry; Wang, Haiyun; Larsen, Nicholas A.; Aquila, Brian M.; Ferguson, Andrew D.; Laing, Naomi M.; Omer, Charles A.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 4 p. 1690 - 1694
