反应条件
1: 87 percent / p-toluenesulfonic acid / CH2Cl2 / 1.67 h / 0 - 20 °C
2: 1.) n-BuLi, hexamethylphosphoramide (HMPA) / 1.) hexane, 5 deg C, 30 min, 2.) RT, overnight
3: p-toluenesulfonic acid / methanol / 1.5 h
4: 48 percent / Li, 1,3-diaminopropane, potassium tert-butoxide / 2 h
View Scheme
参考文献
Menger; Chen; Brocchini; Hopkins; Hamilton
Journal of the American Chemical Society, 1993 , vol. 115, # 15 p. 6600 - 6608
