(R)-2-乙基吡咯烷-1-羧酸叔丁酯合成路线 （共 5 条）
反应条件
hydrogen; palladium 10 on activated carbon in methanol
T=20°C; 20 h;
参考文献
Takeda Pharmaceutical Company Limited
Patent: EP1553074 A1, 2005 ;
Location in patent: Page/Page column 49 ;
反应条件
copper(l) iodide in diethyl ether
T=-20 - -15°C;
参考文献
ELI LILLY AND COMPANY
Patent: WO2006/19833 A1, 2006 ;
Location in patent: Page/Page column 51-52 ;
WO 2006/019833 A1
反应条件
copper(l) iodide in diethyl ether; dichloromethane
T=0°C; 3 h;
参考文献
Fuji, Kaoru; Node, Manabu; Nagasawa, Hideko; Naniwa, Yoshimitsu; Taga, Tooru; et al.
Journal of the American Chemical Society, 1989 , vol. 111, # 20 p. 7921 - 7925
反应条件
trifluoroacetic acid
T=0°C; 0.5 h; Yield given;
参考文献
Takeda Pharmaceutical Company Limited
Patent: EP1553074 A1, 2005 ;
Location in patent: Page/Page column 79 ;
反应条件
hydrogenchloride in 1,4-dioxane
T=20°C; 72 h;
参考文献
ELI LILLY AND COMPANY
Patent: WO2006/19833 A1, 2006 ;
Location in patent: Page/Page column 52 ;
WO 2006/019833 A1
