N-Boc-顺式-4-羟基-L-脯氨酸合成路线 （共 29 条）
反应条件
sodium hydroxide in tetrahydrofuran; water pH=9 - 10;
参考文献
GILEAD SCIENCES, INC.; DESAI, Manoj, C.; HUI, Hon Chung; LIU, Hongtao; SUN, Jianyu; XU, Lianhong
Patent: WO2012/88156 A1, 2012 ;
Location in patent: Page/Page column 60-61 ;
WO 2012/088156 A1
反应条件
1: With sodium hydroxide in ethanol; water 4 h; 2: With citric acid in ethanol; water
参考文献
Chapal, Nicolas; McNicol, Patricia; Jette, Lucie
Patent: US2006/223884 A1, 2006 ;
Location in patent: Page/Page column 60 ;
反应条件
sodium tetrahydroborate in methanol; water T=4°C; 15 h;
参考文献
Mollica, Adriano; Paradisi, Mario Paglialunga; Varani, Katia; Spisani, Susanna; Lucente, Gino
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 7 p. 2253 - 2265
反应条件
water; sodium hydroxide in tetrahydrofuran T=0 - 20°C;
参考文献
Organic Letters, , vol. 13, # 20 p. 5588 - 5591
反应条件
1: 35 percent / CrO3; pyridine / CH2Cl2 / 0.5 h / 0 °C 2: 97 percent / NaBH4 / methanol; H2O / 15 h / 4 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 14, # 7 p. 2253 - 2265
反应条件
lithium hydroxide in ethanol T=20°C; 2 h;
参考文献
Bulletin of the Chemical Society of Japan, , vol. 75, # 11 p. 2517 - 2525
反应条件
1: 100 percent / H2 / 5 percent Pd/C / ethanol / 24 h / 20 °C 2: 91 percent / TBAF / tetrahydrofuran / 20 °C 3: 1.0M LiOH aq. / ethanol / 2 h / 20 °C View Scheme
参考文献
Bulletin of the Chemical Society of Japan, , vol. 75, # 11 p. 2517 - 2525
反应条件
1: 61 percent / Ph3P; DEAD / CH2Cl2; toluene / 48 h / 0 °C 2: 100 percent / H2 / 5 percent Pd/C / ethanol / 24 h / 20 °C 3: 91 percent / TBAF / tetrahydrofuran / 20 °C 4: 1.0M LiOH aq. / ethanol / 2 h / 20 °C View Scheme
参考文献
Bulletin of the Chemical Society of Japan, , vol. 75, # 11 p. 2517 - 2525
反应条件
1: 98 percent / 1.5M HCl / ethanol / 2 h / 20 °C 2: 61 percent / Ph3P; DEAD / CH2Cl2; toluene / 48 h / 0 °C 3: 100 percent / H2 / 5 percent Pd/C / ethanol / 24 h / 20 °C 4: 91 percent / TBAF / tetrahydrofuran / 20 °C 5: 1.0M LiOH aq. / ethanol / 2 h / 20 °C View Scheme
参考文献
Bulletin of the Chemical Society of Japan, , vol. 75, # 11 p. 2517 - 2525
反应条件
1: sodium hydroxide / 1,4-dioxane; water / 0 - 20 °C 2: triphenylphosphine; diethylazodicarboxylate / dichloromethane 3: water; sodium hydroxide / tetrahydrofuran / 0 - 20 °C View Scheme
参考文献
Organic Letters, , vol. 13, # 20 p. 5588 - 5591
