N-Boc-顺式-4-羟基-L-脯氨酸合成路线 （共 29 条）
反应条件
1: sodium hydroxide / 1,4-dioxane; water / 0 - 20 °C 2: triphenylphosphine; diethylazodicarboxylate / dichloromethane 3: water; sodium hydroxide / tetrahydrofuran / 0 - 20 °C View Scheme
参考文献
Organic Letters, , vol. 13, # 20 p. 5588 - 5591
反应条件
1: hydrogenchloride / 1,4-dioxane / 2.5 h / 20 °C 2: triethylamine / N,N-dimethyl-formamide / 72 h 3: triethylamine / 1,4-dioxane 4: sodium hydroxide / ethanol; water / 1 h View Scheme
参考文献
RSC Advances, , vol. 4, # 5 p. 2482 - 2490
反应条件
1: 91 percent / TBAF / tetrahydrofuran / 20 °C 2: 1.0M LiOH aq. / ethanol / 2 h / 20 °C View Scheme
参考文献
Bulletin of the Chemical Society of Japan, , vol. 75, # 11 p. 2517 - 2525
反应条件
sodium hydride in tetrahydrofuran 4 h;
参考文献
Krishnamurthy, Suvratha; Arai, Toru; Nakanishi, Kanae; Nishino, Norikazu
RSC Advances, 2014 , vol. 4, # 5 p. 2482 - 2490
反应条件
1: 62 percent / aq. NaOH / diethyl ether / 24 h 2: 36 percent / lithium triethylborodeuteride / tetrahydrofuran / 24 h / Heating 3: trifluoroacetic acid / 0.5 h 4: TES buffer, iron(II)ammonium sulphate, 2-oxoglutarate, proline 4-hydroxylase / 4 h / 26 °C / incubation View Scheme
参考文献
Baldwin, Jack E.; Field, Robert A.; Lawrence, Christopher C.; Merritt, Kirsten D.; Schofield, Christopher J.
Tetrahedron Letters, 1993 , vol. 34, # 46 p. 7489 - 7492
反应条件
hydrogenchloride; sodium hydroxide in N-methyl-acetamide; methanol; hexane; water
参考文献
Scios Inc.
Patent: US6288036 B1, 2001 ;
反应条件
pyridine; chromium(VI) oxide 1.) CH2Cl2, 0 deg C, 5 min; 2.) CHCl2, 4 h, r.t.; Yield given. Multistep reaction;
参考文献
Herdewijn; Claes; Vanderhaeghe
Canadian Journal of Chemistry, 1982 , vol. 60, # 23 p. 2903 - 2907
反应条件
potassium carbonate in acetone T=20°C;
参考文献
Tetrahedron Letters, , vol. 50, # 25 p. 3054 - 3058
反应条件
in methanol; diethyl ether
参考文献
Bioorganic and Medicinal Chemistry, , vol. 17, # 1 p. 251 - 259
反应条件
1: With hydrogenchloride in 1,4-dioxane T=20°C; 19 h; 2: With TEA in ethanol
参考文献
Kimura, Rumi; Nagano, Tanemasa; Kinoshita, Hideki
Bulletin of the Chemical Society of Japan, 2002 , vol. 75, # 11 p. 2517 - 2525
