3-(1-哌嗪基)-1,2-苯并异噻唑合成路线 （共 30 条）
反应条件
1: With methanesulfonyl chloride; triethylamine in methanol; acetonitrile T=0 - 20°C; 2: With ammonium hydroxide Reflux;
参考文献
MAPI PHARMA LTD.; MARON, Ehud; MIZHIRITSKII, Michael; TCHILIBON, Susanna; RUBNOV, Shai
Patent: WO2013/14665 A1, 2013 ;
Location in patent: Page/Page column 22; 23 ;
参考文献
Yevich, Joseph P.; New, James S.; Smith, David W.; Lobeck, Walter G.; Catt, John D.; et al.
Journal of Medicinal Chemistry, 1986 , vol. 29, # 3 p. 359 - 369
反应条件
in methanol; isopropyl alcohol
参考文献
PFIZER INC.
Patent: EP790236 A1, 1997 ;
参考文献
US4487773 A1, ;
US 4487773 A
反应条件
1: Cl2 / CH2Cl2 2: concd NH4OH / CH2Cl2 / 1 h 3: 77 percent / POCl3 / 3.5 h / 20 - 120 °C 4: 68 percent / 24 h / 125 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 29, # 3 p. 359 - 369
反应条件
1: 71 percent / SOCl2 / dimethylformamide; toluene / 18 h / 75 °C 2: Cl2 / CH2Cl2 3: concd NH4OH / CH2Cl2 / 1 h 4: 77 percent / POCl3 / 3.5 h / 20 - 120 °C 5: 68 percent / 24 h / 125 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 29, # 3 p. 359 - 369
反应条件
1: concd NH4OH / CH2Cl2 / 1 h 2: 77 percent / POCl3 / 3.5 h / 20 - 120 °C 3: 68 percent / 24 h / 125 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 29, # 3 p. 359 - 369
反应条件
1: 77 percent / POCl3 / 3.5 h / 20 - 120 °C 2: 68 percent / 24 h / 125 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 29, # 3 p. 359 - 369
反应条件
1: 87 percent / K2CO3, KI / dimethylformamide / 3 h / 90 - 100 °C 2: 86.2 percent / hydrazine hydrate / methanol / 2.5 h / Heating View Scheme
参考文献
Norman, Mark H.; Rigdon, Greg C.; Navas, Frank; Cooper, Barrett R.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 16 p. 2552 - 2563
