3-(1-哌嗪基)-1,2-苯并异噻唑合成路线 （共 30 条）
反应条件
in methanol; water UV-irradiation;
参考文献
Sharp, Thomas R.; Leeman, Kyle R.; Bryant, D. Eugene; Horan, George J.
Tetrahedron Letters, 2003 , vol. 44, # 8 p. 1559 - 1561
反应条件
1: With potassium carbonate in anhydrous xylene 40 h; Reflux; 2: With hydrogenchloride in anhydrous xylene; water; ethyl acetate
参考文献
WO2013/14665 A1, ;
Page/Page column 22 ;
反应条件
sodium carbonate in acetonitrile T=80 - 85°C; 24 h;
参考文献
SHASUN PHARMACEUTICALS LIMITED; VIJAYABASKAR, V.; SRIMURUGAN, S.; KUMAR, R.V. Sathish; JAYAMANI, Munusamy
Patent: WO2013/190455 A2, 2013 ;
Location in patent: Page/Page column 13; 14 ;
反应条件
sodium carbonate in acetonitrile T=30°C; 20 h; Reflux;
参考文献
RANBAXY LABORATORIES LIMITED; JAYACHANDRA, Suresh Babu; GAHLOT, Udaibhan Singh; SINGH, Tarun Kumar
Patent: WO2014/37886 A1, 2014 ;
Location in patent: Page/Page column 21 ;
反应条件
1: 89 percent / CH2Cl2 / 3 h / 0 - 20 °C 2: 92 percent / 0.1 M NaIO4 / methanol / 48 h / Ambient temperature 3: 66 percent / 1 N HCl / 3 h / Heating View Scheme
参考文献
Cipollina, Joseph A.; Ruediger, Edward H.; New, James S.; Wire, Mary E.; Shepherd, Timothy A.; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 11 p. 3316 - 3328
反应条件
in dichloromethane T=0 - 20°C; 3 h;
参考文献
Cipollina, Joseph A.; Ruediger, Edward H.; New, James S.; Wire, Mary E.; Shepherd, Timothy A.; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 11 p. 3316 - 3328
反应条件
in water Inert atmosphereRefluxdispersing agent;
参考文献
ALKEM LABORATORIES LIMITED
Patent: US2011/3995 A1, 2011 ;
Location in patent: Page/Page column 5 ;
反应条件
tetrabutyl-ammonium chloride; sodium carbonate; sodium iodide in water T=25 - 30°C; 9 h; Reflux;
参考文献
RICHTER GEDEON NYRT.
Patent: WO2007/125374 A2, 2007 ;
Location in patent: Page/Page column 7 ;
反应条件
pyridine; methylamine in water T=80°C; 10 h; Product distribution / selectivity;
参考文献
HETERO DRUGS LIMITED
Patent: WO2006/80025 A1, 2006 ;
Location in patent: Page/Page column 16 ;
反应条件
tetrabutylammomium bromide; sodium carbonate; sodium iodide in cyclohexane Heating / reflux;
参考文献
Venkataraman, Sundaram; Rao, Uppala Venkata Bhaskara; Muvva, Venkateswarlu; Chitta, Vijayawardhan
Patent: US2006/89502 A1, 2006 ;
Location in patent: Page/Page column 7 ;
