3-(1-哌嗪基)-1,2-苯并异噻唑合成路线 （共 30 条）
反应条件
sulfuric acid; nitric acid T=-10°C;
参考文献
Cipollina, Joseph A.; Ruediger, Edward H.; New, James S.; Wire, Mary E.; Shepherd, Timothy A.; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 11 p. 3316 - 3328
反应条件
in water Inert atmosphereRefluxdispersing agent;
参考文献
ALKEM LABORATORIES LIMITED
Patent: US2011/3995 A1, 2011 ;
Location in patent: Page/Page column 5 ;
反应条件
tetrabutyl-ammonium chloride; sodium carbonate; sodium iodide in water T=25 - 30°C; 9 h; Reflux;
参考文献
RICHTER GEDEON NYRT.
Patent: WO2007/125374 A2, 2007 ;
Location in patent: Page/Page column 7 ;
反应条件
pyridine; methylamine in water T=80°C; 10 h; Product distribution / selectivity;
参考文献
HETERO DRUGS LIMITED
Patent: WO2006/80025 A1, 2006 ;
Location in patent: Page/Page column 16 ;
反应条件
tetrabutylammomium bromide; sodium carbonate; sodium iodide in cyclohexane Heating / reflux;
参考文献
Venkataraman, Sundaram; Rao, Uppala Venkata Bhaskara; Muvva, Venkateswarlu; Chitta, Vijayawardhan
Patent: US2006/89502 A1, 2006 ;
Location in patent: Page/Page column 7 ;
反应条件
potassium carbonate; potassium iodide in N,N-dimethyl-formamide T=90 - 100°C; 7 h;
参考文献
Ishizumi; Kojima; Antoku; Saji; Yoshigi
Chemical and Pharmaceutical Bulletin, 1995 , vol. 43, # 12 p. 2139 - 2151
反应条件
potassium carbonate; sodium iodide in acetonitrile T=80°C; 18 h;
参考文献
Hrib; Jurcak; Huger; Errico; Dunn
Journal of Medicinal Chemistry, 1991 , vol. 34, # 3 p. 1068 - 1072
反应条件
potassium iodide; potassium carbonate in chloroform; acetonitrile
参考文献
Mead Johnson and Company
Patent: US4411901 A1, 1983 ;
反应条件
1: 91 percent / K2CO3, 18-crown-6 / aq. ethanol / 24 h / Heating
2: 88 percent / K2CO3, 18-crown-6 / toluene / 22 h / Heating
View Scheme
参考文献
Yevich, Joseph P.; New, James S.; Smith, David W.; Lobeck, Walter G.; Catt, John D.; et al.
Journal of Medicinal Chemistry, 1986 , vol. 29, # 3 p. 359 - 369
反应条件
potassium carbonate; potassium iodide in acetonitrile
20 h; Heating;
参考文献
Yevich, Joseph P.; New, James S.; Smith, David W.; Lobeck, Walter G.; Catt, John D.; et al.
Journal of Medicinal Chemistry, 1986 , vol. 29, # 3 p. 359 - 369
