18-crown-6 ether; potassium carbonate in toluene 22 h; Heating;

potassium iodide; potassium carbonate in chloroform; acetonitrile

1: Cl2 / CH2Cl2 2: concd NH4OH / CH2Cl2 / 1 h 3: 77 percent / POCl3 / 3.5 h / 20 - 120 °C 4: 68 percent / 24 h / 125 °C 5: 91 percent / K2CO3, 18-crown-6 / aq. ethanol / 24 h / Heating 6: 88 percent / K2CO3, 18-crown-6 / toluene / 22 h / Heating View Scheme

1: 68 percent / 24 h / 125 °C 2: 91 percent / K2CO3, 18-crown-6 / aq. ethanol / 24 h / Heating 3: 88 percent / K2CO3, 18-crown-6 / toluene / 22 h / Heating View Scheme

1: 77 percent / POCl3 / 3.5 h / 20 - 120 °C 2: 68 percent / 24 h / 125 °C 3: 91 percent / K2CO3, 18-crown-6 / aq. ethanol / 24 h / Heating 4: 88 percent / K2CO3, 18-crown-6 / toluene / 22 h / Heating View Scheme

1: 71 percent / SOCl2 / dimethylformamide; toluene / 18 h / 75 °C 2: Cl2 / CH2Cl2 3: concd NH4OH / CH2Cl2 / 1 h 4: 77 percent / POCl3 / 3.5 h / 20 - 120 °C 5: 68 percent / 24 h / 125 °C 6: 91 percent / K2CO3, 18-crown-6 / aq. ethanol / 24 h / Heating 7: 88 percent / K2CO3, 18-crown-6 / toluene / 22 h / Heating View Scheme

1: concd NH4OH / CH2Cl2 / 1 h 2: 77 percent / POCl3 / 3.5 h / 20 - 120 °C 3: 68 percent / 24 h / 125 °C 4: 91 percent / K2CO3, 18-crown-6 / aq. ethanol / 24 h / Heating 5: 88 percent / K2CO3, 18-crown-6 / toluene / 22 h / Heating View Scheme

1: 91 percent / K2CO3, 18-crown-6 / aq. ethanol / 24 h / Heating 2: 88 percent / K2CO3, 18-crown-6 / toluene / 22 h / Heating View Scheme

potassium carbonate; potassium iodide in acetonitrile 20 h; Heating;