N-(叔丁氧基羰基)-L-亮氨酸-N′-甲氧基-N′-甲酰胺合成路线 （共 15 条）
反应条件
1: N-tert-butoxycarbonyl-L-leucine With N-ethyl-N,N-diisopropylamine; [bis(2-methoxyethyl)amino]-sulfur trifluoride in dichloromethane T=0°C; 0.25 h; 2: N,O-dimethyl-hydroxylamine in dichloromethane T=0 - 20°C; 6 h; Further stages.;
参考文献
Organic Letters, , vol. 2, # 25 p. 4091 - 4093
反应条件
1: N-tert-butoxycarbonyl-L-leucine With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in dichloromethane T=0°C; 0.25 h; Inert atmosphere; 2: O,N-dimethyl-hydroxylamine hydrochloride With 4-methyl-morpholine in dichloromethane T=0 - 25°C; 14 h; Inert atmosphere;
参考文献
Journal of the American Chemical Society, , vol. 133, # 3 p. 462 - 477
反应条件
1: O,N-dimethyl-hydroxylamine hydrochloride With 1-methyl-piperidine in dichloromethane T=0°C; 0.5 h; 2: N-tert-butoxycarbonyl-L-leucine; isobutyl chloroformate in tetrahydrofuran; dichloromethane T=-20°C; 0.583333 h;
参考文献
US2008/125467 A1, ;
Page/Page column 21-22 ;
反应条件
1-methyl-piperidine in tetrahydrofuran; dichloromethane
参考文献
US2004/121947 A1, ;
US 20040121947 A1
反应条件
triethylamine in dichloromethane
反应条件
O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate in N,N-dimethyl-formamide
参考文献
US6251918 B1, ;
US 6251918 B1
反应条件
(benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine in dichloromethane 1 h;
参考文献
Bulletin de la Societe Chimique de France, , vol. 2, # 7-8 p. 230 - 232
反应条件
in N-methyl-acetamide
参考文献
US5731286 A1, ;
US 5731286 A
反应条件
1: 96 percent / aq. NaOH / dioxane / 68 h / 20 °C 2: 73 percent / Et3N; bis(2-oxo-3-oxazolidinyl)phosphinic chloride / CH2Cl2 / 1 h / 0 °C View Scheme
参考文献
Synthesis, , # 14 p. 2161 - 2164
反应条件
1: 96 percent / aq. NaOH / dioxane / 68 h / 20 °C 2: 73 percent / Et3N; bis(2-oxo-3-oxazolidinyl)phosphinic chloride / CH2Cl2 / 1 h / 0 °C View Scheme
参考文献
Synthesis, , # 14 p. 2161 - 2164
