N-(叔丁氧基羰基)-L-亮氨酸-N′-甲氧基-N′-甲酰胺合成路线 （共 15 条）
反应条件
4-methyl-morpholine; isobutoxy chloroformate 1.) ethyl acetate, 15 min, ice bath, 2a.) 15 min, ice bath, 2b.) 20h, RT; Yield given. Multistep reaction;
参考文献
Synthesis, , # 6 p. 453 - 454
反应条件
1: tetrahydrofuran / 2 h / 0 °C / Inert atmosphere 2: dichloromethane / 16 h / Inert atmosphere View Scheme
参考文献
Journal of Organic Chemistry, , vol. 76, # 15 p. 6209 - 6217
反应条件
in dichloromethane 16 h; Inert atmosphere;
参考文献
Journal of Organic Chemistry, , vol. 76, # 15 p. 6209 - 6217
反应条件
1: 92 percent / diethyl ether / 2.5 h / -78 °C 2: H2O2, i-PrEtN / benzonitrile; H2O; methanol / 43 h / 0 - 4 °C View Scheme
参考文献
CREIGHTON UNIVERSITY; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; MURRAY, Thomas F.; GERWICK, William H.; PEREIRA-BADILLA, Alban R.; KALE, Andrew; BYRUM, Tara; DEBONSI, Hosana; MOORE, Bradley S.; GILSON, Michael Kenneth; FENLEY, Andrew
Patent: WO2013/9923 A1, 2013 ;
反应条件
1.1: BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C 1.2: 74 percent / tetrahydrofuran; hexane / 0.67 h / 0 °C 2.1: BH3*SMe2 / (S)-oxazaborolidine / tetrahydrofuran / 0 °C 3.1: dicyclohexylborane / tetrahydrofuran / 2 h / 0 - 20 °C 3.2: aq. H2O2 / aq. NaHCO3 / 20 °C 3.3: AcOH / 0 - 20 °C View Scheme
参考文献
Alemany, Carme; Bach, Jordi; Garcia, Jordi; Lopez, Marta; Rodriguez, Ana B.
Tetrahedron, 2000 , vol. 56, # 47 p. 9305 - 9312
