N-(叔丁氧基羰基)-L-缬氨酸N-甲氧基-N-甲基酰胺合成路线 （共 9 条）
反应条件
(benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine in N,N-dimethyl-formamide T=4°C;
参考文献
Valverde, Ibai E.; Huxol, Elena; Mindt, Thomas L.
Journal of Labelled Compounds and Radiopharmaceuticals, 2014 , vol. 57, # 4 p. 275 - 278
反应条件
1: With triethylamine T=0°C; 2: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine
参考文献
Falkiewicz; Wisniowski; Kolodziejczyk; Wisniewski
Nucleosides, Nucleotides and Nucleic Acids, 2001 , vol. 20, # 4-7 p. 1393 - 1397
参考文献
Tetrahedron Letters, , vol. 35, # 19 p. 3183 - 3186
反应条件
triethylamine in dichloromethane
参考文献
Accuthera, Inc.
Patent: US2009/156509 A1, 2009 ;
US 20090156509 A1
反应条件
in dichloromethane T=0 - 20°C; 6.25 h;
参考文献
Journal of Organic Chemistry, , vol. 69, # 7 p. 2573 - 2576
反应条件
4-methyl-morpholine; isobutyl chloroformate in dichloromethane
参考文献
Tetrahedron Letters, , vol. 43, # 41 p. 7389 - 7392
反应条件
in dichloromethane 16 h; Inert atmosphere;
参考文献
Journal of Organic Chemistry, , vol. 76, # 15 p. 6209 - 6217
反应条件
1: Boc-Val-NMe(OMe) With diisobutylaluminium hydride in dichloromethane T=-78°C; 0.666667 h; 2: Bestman-Ohira reagent With potassium carbonate in dichloromethane T=20°C; 8 h; Further stages.;
参考文献
Tam, Annie; Arnold, Ulrich; Soellner, Matthew B.; Raines, Ronald T.
Journal of the American Chemical Society, 2007 , vol. 129, # 42 p. 12670 - 12671
反应条件
lithium aluminium tetrahydride in diethyl ether
T=0°C; 0.5 h;
参考文献
Hasuoka, Atsushi; Nishikimi, Yuji; Nakayama, Yutaka; Kamiyama, Keiji; Nakao, Masafumi; Miyagawa, Ken-Ichiro; Nishimura, Osamu; Fujino, Masahiko
Journal of Antibiotics, 2002 , vol. 55, # 3 p. 322 - 336
