2 -溴- 4 -氯苯丙酮合成路线 （共 19 条）
反应条件
hydrogen bromide; bromine in dichloromethane
0.25 h;
参考文献
NOVARTIS AG
Patent: WO2009/40410 A1, 2009 ;
Location in patent: Page/Page column 73 ;
WO 2009/040410 A1
参考文献
Nihon Bayer Agrochem K.K.
Patent: US5389648 A1, 1995 ;
反应条件
1.1: iodine; magnesium / diethyl ether / Inert atmosphere
1.2: 6 h / Reflux
1.3: Heating
2.1: bromine / diethyl ether / 20 °C / Cooling with ice
View Scheme
参考文献
Lagoja, Irene; Pannecouque, Christophe; Griffioen, Gerard; Wera, Stefaan; Rojasdelaparra, Veronica Maria; Van Aerschot, Arthur
European Journal of Pharmaceutical Sciences, 2011 , vol. 43, # 5 p. 386 - 392
反应条件
1: diethyl ether / 3 h / 0 °C
2: acetic acid; hydrogen bromide; bromine / 1 h
View Scheme
参考文献
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA; BALLATORE, Carlo; BRUNDEN, Kurt, R.; HOYE, Adam, T.; LEE, Virginia, M.y.; SMITH, Amos, B.; TROJANOWSKI, John, Q.
Patent: WO2014/47257 A2, 2014 ;
反应条件
1: 4-methyl-morpholine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 12 h / 0 °C
2: diethyl ether / 3 h / 0 °C
3: acetic acid; hydrogen bromide; bromine / 1 h
View Scheme
参考文献
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA; BALLATORE, Carlo; BRUNDEN, Kurt, R.; HOYE, Adam, T.; LEE, Virginia, M.y.; SMITH, Amos, B.; TROJANOWSKI, John, Q.
Patent: WO2014/47257 A2, 2014 ;
反应条件
aluminium trichloride
参考文献
Collet
Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1898 , vol. 126, p. 1578
反应条件
1: 42 percent / NaH / tetrahydrofuran / 1.5 h / Heating
2: sodium / ethanol / 2.5 h / 0 °C
View Scheme
参考文献
Dutta, Aloke K.; Sard, Howard; Ryan, William; Razdan, Raj K.; Compton, David R.; Martin, Billy R.
Medicinal Chemistry Research, 1995 , vol. 5, # 1 p. 54 - 62
反应条件
sodium hydride in methanol
T=25°C; 0.25 h;
参考文献
Duh, Tsai-Hui; Wang, Yi-Fong; Wu, Ming-Jung
Journal of the Chinese Chemical Society (Taipei, Taiwan), 1995 , vol. 42, # 3 p. 579 - 584
反应条件
1: 1H-1,2,4-triazol With sodium hydride in DMF (N,N-dimethyl-formamide)
T=20 - 30°C; 1.5 h; Cooling with ice-bath;
2: 2-bromo-1-(4-chlorophenyl)-1-propanone in DMF (N,N-dimethyl-formamide)
T=20 - 30°C;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2004/11410 A1, 2004 ;
Location in patent: Page 125 ;
WO 2004/011410 A1
