4-(三甲基甲硅烷基)苯甲醚合成路线 （共 34 条）
反应条件
n-butyllithium in tetrahydrofuran; hexane T=0 - 20°C; 1 h; Inert atmosphere;
参考文献
Cren, Sylvaine; Schar, Pascal; Renaud, Philippe; Schenk, Kurt
Journal of Organic Chemistry, 2009 , vol. 74, # 8 p. 2942 - 2946
反应条件
1: With n-butyllithium in tetrahydrofuran; hexanes T=-78°C; 0.25 h; 2: With chloro-trimethyl-silane T=20°C;
参考文献
AMEDIS PHARMACEUTICALS LTD.
Patent: WO2005/44825 A1, 2005 ;
Location in patent: Page/Page column 13; 18 ;
反应条件
diphenyl-(o-hydroxyphenyl)-phosphine; tetrabutylammomium bromide; PdCl(π-C3H5)2 in toluene T=100°C; Substitution; Silylation; 24 h;
参考文献
Shirakawa; Kurahashi; Yoshida; Hiyama
Chemical Communications, 2000 , # 19 p. 1895 - 1896
反应条件
potassium fluoride; water; 2-dicyclohexylphosphino-1,1'-biphenyl; tris-(dibenzylideneacetone)dipalladium(0) in 1,4-dioxane T=100°C; 24 h;
参考文献
McNeill, Eric; Barder, Timothy E.; Buchwald, Stephen L.
Organic Letters, 2007 , vol. 9, # 19 p. 3785 - 3788
反应条件
sodium hydroxide; diphenyl-(o-hydroxyphenyl)-phosphine; PdCl(π-C3H5)2 in tetrahydrofuran T=100°C; Substitution; Silylation; 24 h;
参考文献
Shirakawa; Kurahashi; Yoshida; Hiyama
Chemical Communications, 2000 , # 19 p. 1895 - 1896
反应条件
[RhCl(η2:η2-cycloocta-1,5-diene)]2 in various solvent(s) T=130°C; 40 h;
参考文献
Tobisu, Mamoru; Kita, Yusuke; Ano, Yusuke; Chatani, Naoto
Journal of the American Chemical Society, 2008 , vol. 130, # 47 p. 15982 - 15989
反应条件
[RhCl(η2:η2-cycloocta-1,5-diene)]2; tris(p-fluoro phenyl)phosphine in 2-cyclohexylethanol T=130°C; Mizoroki-Heck type reaction; 30 h; Inert atmosphere;
参考文献
Organic Letters, , vol. 12, # 8 p. 1864 - 1867
反应条件
NO2BF4 in water; acetonitrile
参考文献
Boehringer Ingelheim Pharmaceuticals, Inc.
Patent: US2003/8868 A1, 2003 ;
反应条件
sodium in tetrahydrofuran T=80°C; 24 h; chemoselective reaction;
参考文献
Iijima, Akinori; Amii, Hideki
Tetrahedron Letters, 2008 , vol. 49, # 41 p. 6013 - 6015
参考文献
Journal of the American Chemical Society, , vol. 75, p. 4528,4529
Journal of the American Chemical Society, , vol. 72, p. 2629,2631
