1: With methyllithium in tetrahydrofuran; diethyl ether; pentane
T=-78°C; 1 h;
2: With tert.-butyl lithium in tetrahydrofuran; diethyl ether; pentane
T=-78°C; 1 h;
3: With boric acid trimethyl ester; water
more than 3 stages;
参考文献
GALDERMA RESEARCH and DEVELOPMENT
Patent: US2009/12129 A1, 2009 ;
Location in patent: Page/Page column 30 ;
1: N-(3-bromophenyl)-N-methylamine With methyllithium in tetrahydrofuran
T=-70°C; 1 h;
2: With tert.-butyl lithium in tetrahydrofuran
T=-70°C; 0.75 h;
3: boric acid trimethyl ester With hydrogenchloride; water
more than 3 stages;
参考文献
GALDERMA RESEARCH and DEVELOPMENT, S.N.C.
Patent: WO2006/53791 A2, 2006 ;
Location in patent: Page/Page column 44-45 ;
WO 2006/053791 A2