potassium hydroxide in water; tert-butyl alcohol 168 h; Ambient temperature;

1: 63 percent / H2O2, AcOH / 20 h / 90 °C 2: 58 percent / 3 h / Heating 3: 72 percent / 10percent HCl / Heating 4: 51 percent / polyphosphoric acid / 0.67 h / 90 - 100 °C 5: N-bromoacetamide, AcOH / 3 h / Ambient temperature 6: 79 percent / MeONa / tetrahydrofuran / 4 h / Ambient temperature 7: N-bromosuccinimide, azoisobutyronitrile / CCl4 / 0.67 h / 60 - 70 °C 8: 62 percent / MeONa / tetrahydrofuran / 1) 0 deg C, 1 h, 2) rt, 3 h 9: 27 percent / KOH / H2O; 2-methyl-propan-2-ol / 168 h / Ambient temperature View Scheme

1: N-bromoacetamide, AcOH / 3 h / Ambient temperature 2: 79 percent / MeONa / tetrahydrofuran / 4 h / Ambient temperature 3: N-bromosuccinimide, azoisobutyronitrile / CCl4 / 0.67 h / 60 - 70 °C 4: 62 percent / MeONa / tetrahydrofuran / 1) 0 deg C, 1 h, 2) rt, 3 h 5: 27 percent / KOH / H2O; 2-methyl-propan-2-ol / 168 h / Ambient temperature View Scheme

1: 58 percent / 3 h / Heating 2: 72 percent / 10percent HCl / Heating 3: 51 percent / polyphosphoric acid / 0.67 h / 90 - 100 °C 4: N-bromoacetamide, AcOH / 3 h / Ambient temperature 5: 79 percent / MeONa / tetrahydrofuran / 4 h / Ambient temperature 6: N-bromosuccinimide, azoisobutyronitrile / CCl4 / 0.67 h / 60 - 70 °C 7: 62 percent / MeONa / tetrahydrofuran / 1) 0 deg C, 1 h, 2) rt, 3 h 8: 27 percent / KOH / H2O; 2-methyl-propan-2-ol / 168 h / Ambient temperature View Scheme

1: N-bromosuccinimide, azoisobutyronitrile / CCl4 / 0.67 h / 60 - 70 °C 2: 62 percent / MeONa / tetrahydrofuran / 1) 0 deg C, 1 h, 2) rt, 3 h 3: 27 percent / KOH / H2O; 2-methyl-propan-2-ol / 168 h / Ambient temperature View Scheme

1: 51 percent / polyphosphoric acid / 0.67 h / 90 - 100 °C 2: N-bromoacetamide, AcOH / 3 h / Ambient temperature 3: 79 percent / MeONa / tetrahydrofuran / 4 h / Ambient temperature 4: N-bromosuccinimide, azoisobutyronitrile / CCl4 / 0.67 h / 60 - 70 °C 5: 62 percent / MeONa / tetrahydrofuran / 1) 0 deg C, 1 h, 2) rt, 3 h 6: 27 percent / KOH / H2O; 2-methyl-propan-2-ol / 168 h / Ambient temperature View Scheme

1: 62 percent / MeONa / tetrahydrofuran / 1) 0 deg C, 1 h, 2) rt, 3 h 2: 27 percent / KOH / H2O; 2-methyl-propan-2-ol / 168 h / Ambient temperature View Scheme

1: 72 percent / 10percent HCl / Heating 2: 51 percent / polyphosphoric acid / 0.67 h / 90 - 100 °C 3: N-bromoacetamide, AcOH / 3 h / Ambient temperature 4: 79 percent / MeONa / tetrahydrofuran / 4 h / Ambient temperature 5: N-bromosuccinimide, azoisobutyronitrile / CCl4 / 0.67 h / 60 - 70 °C 6: 62 percent / MeONa / tetrahydrofuran / 1) 0 deg C, 1 h, 2) rt, 3 h 7: 27 percent / KOH / H2O; 2-methyl-propan-2-ol / 168 h / Ambient temperature View Scheme

1: 79 percent / MeONa / tetrahydrofuran / 4 h / Ambient temperature 2: N-bromosuccinimide, azoisobutyronitrile / CCl4 / 0.67 h / 60 - 70 °C 3: 62 percent / MeONa / tetrahydrofuran / 1) 0 deg C, 1 h, 2) rt, 3 h 4: 27 percent / KOH / H2O; 2-methyl-propan-2-ol / 168 h / Ambient temperature View Scheme