2-氯-4-碘-5-(甲氧基甲氧基)吡啶合成路线 （共 2 条）
反应条件
1.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C
1.2: 20 °C
2.1: n-butyllithium / tetrahydrofuran / 1 h / -78 °C
2.2: 1 h / -78 °C
View Scheme
参考文献
NOVARTIS AG; FURET, Pascal; GUAGNANO, Vito; HOLZER, Philipp; MAH, Robert; MASUYA, Keiichi; SCHLAPBACH, Achim; STUTZ, Stefan; VAUPEL, Andrea
Patent: WO2013/80141 A1, 2013 ;
反应条件
1: With hydrogenchloride; water in tetrahydrofuran
T=60°C; 3 h;
2: With sodium hydrogencarbonate in tetrahydrofuran; water
T=20°C; pH=7;
参考文献
ELI LILLY AND COMPANY
Patent: WO2008/144222 A2, 2008 ;
Location in patent: Page/Page column 25 ;
