2-氨基-5-氟-3’,4’-二氯联苯合成路线 （共 11 条）
反应条件
sodium hydroxide; triphenylphosphine; palladium dichloride in 1,4-dioxane; water
T=85°C; 6 h;
参考文献
BASF AKTIENGESELLSCHAFT
Patent: WO2007/138089 A1, 2007 ;
Location in patent: Page/Page column 9-10 ;
反应条件
potassium phosphate; 1,1'-bis(di-tert-butylphosphino)ferrocene palladium dichloride in water; toluene
T=79 - 81°C; 2 h; Inert atmosphere; Product distribution / selectivity;
参考文献
Bayer CropScience AG
Patent: US2010/185015 A1, 2010 ;
Location in patent: Page/Page column 5 ;
反应条件
sodium hydroxide in water; acetonitrile
T=70 - 75°C;
参考文献
BASF SE; Heinrich, Markus; Pratsch, Gerald
Patent: US2013/338369 A1, 2013 ;
Location in patent: Paragraph 0243; 0244; 0290; 0291; 0292; 0293; 0294-0297 ;
反应条件
manganese(IV) oxide in acetonitrile
T=20°C; regioselective reaction;
参考文献
Jasch, Hannelore; Scheumann, Julia; Heinrich, Markus R.
Journal of Organic Chemistry, 2012 , vol. 77, # 23 p. 10699 - 10706
反应条件
oxygen; sodium hydroxide in water
T=60°C; 33 h; regioselective reaction;
参考文献
Hofmann, Josefa; Jasch, Hannelore; Heinrich, Markus R.
Journal of Organic Chemistry, 2014 , vol. 79, # 5 p. 2314 - 2320
反应条件
1: sodium nitrite; tetrafluorohydroboric acid / water / 0.5 h / 0 - 5 °C
2: 75 °C
View Scheme
参考文献
Pratsch, Gerald; Wallaschkowski, Tina; Heinrich, Markus R.
Chemistry--A European Journal, 2012 , vol. 18, # 37 p. 11555 - 11559,5
Title/Abstract Full Text Show Details
Pratsch, Gerald; Wallaschkowski, Tina; Heinrich, Markus R.
Chemistry - A European Journal, 2012 , vol. 18, # 37 p. 11555 - 11559
反应条件
T=75°C; Gomberg-Bachman Arylation; regioselective reaction;
参考文献
Pratsch, Gerald; Wallaschkowski, Tina; Heinrich, Markus R.
Chemistry--A European Journal, 2012 , vol. 18, # 37 p. 11555 - 11559,5
Title/Abstract Full Text Show Details
Pratsch, Gerald; Wallaschkowski, Tina; Heinrich, Markus R.
Chemistry - A European Journal, 2012 , vol. 18, # 37 p. 11555 - 11559
反应条件
potassium hydroxide; water in 2-methoxy-ethanol
T=100°C; 4 h; Product distribution / selectivity;
参考文献
BAYER CROPSCIENCE AG
Patent: WO2006/24388 A1, 2006 ;
Location in patent: Page/Page column 19 ;
反应条件
triethylamine in tetrahydrofuran
T=60°C; 16 h; Reflux;
参考文献
BASF SE; Heinrich, Markus; Pratsch, Gerald
Patent: US2013/338369 A1, 2013 ;
Location in patent: Paragraph 0397 ;
反应条件
sodium methylate in 1-methyl-pyrrolidin-2-one; methanol; toluene
T=70°C; P=375.038 Torr; 1 h; Temperature;
参考文献
Moradi, Wahed Ahmed; Lui, Norbert; Dockner, Michael
Patent: US2014/128617 A1, 2014 ;
Location in patent: Paragraph 0090; 0091 ;
