5-乙酰基-1H-吲唑-1-羧酸,1,1-二甲基乙酯合成路线 （共 8 条）
反应条件
1: With hydrogenchloride; water in tetrahydrofuran 25 h; 2: With sodium carbonate in water; ethyl acetate
参考文献
PFIZER JAPAN INC.; PFIZER INC.
Patent: WO2008/7211 A1, 2008 ;
Location in patent: Page/Page column 42 ;
WO 2008/007211 A1
反应条件
mono-1,1-dimethylethylphosphine; N,N-dicyclohexylmethylamine; tris-(dibenzylideneacetone)dipalladium(0) in 1,4-dioxane
T=40°C; 17.5 h;
参考文献
PFIZER JAPAN INC.; PFIZER INC.
Patent: WO2008/7211 A1, 2008 ;
Location in patent: Page/Page column 42 ;
WO 2008/007211 A1
反应条件
bis-triphenylphosphine-palladium(II) chloride in toluene
T=100°C;
参考文献
ABBOTT LABORATORIES
Patent: WO2008/154241 A1, 2008 ;
Location in patent: Page/Page column 70 ;
反应条件
4-(N,N-dimethlyamino)pyridine in dichloromethane
T=20°C;
参考文献
Akritopoulou-Zanze, Irini; Wakefield, Brian D.; Gasiecki, Alan; Kalvin, Douglas; Johnson, Eric F.; Kovar, Peter; Djuric, Stevan W.
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 5 p. 1480 - 1483
反应条件
1: tetrahydrofuran / 0 - 20 °C
2: 4-(N,N-dimethlyamino)pyridine / dichloromethane / 20 °C
View Scheme
参考文献
Akritopoulou-Zanze, Irini; Wakefield, Brian D.; Gasiecki, Alan; Kalvin, Douglas; Johnson, Eric F.; Kovar, Peter; Djuric, Stevan W.
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 5 p. 1480 - 1483
反应条件
1: 4-(N,N-dimethlyamino)pyridine / dichloromethane / 20 °C
2: bis-triphenylphosphine-palladium(II) chloride / toluene / 100 °C
View Scheme
参考文献
Akritopoulou-Zanze, Irini; Wakefield, Brian D.; Gasiecki, Alan; Kalvin, Douglas; Johnson, Eric F.; Kovar, Peter; Djuric, Stevan W.
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 5 p. 1480 - 1483
反应条件
1: 4-(N,N-dimethlyamino)pyridine / dichloromethane / 20 °C
2: bis-triphenylphosphine-palladium(II) chloride / toluene / 100 °C
View Scheme
参考文献
Akritopoulou-Zanze, Irini; Wakefield, Brian D.; Gasiecki, Alan; Kalvin, Douglas; Johnson, Eric F.; Kovar, Peter; Djuric, Stevan W.
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 5 p. 1480 - 1483
反应条件
1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane; N,N-dimethyl-formamide / 24 h / 20 °C
2: tetrahydrofuran / 0 - 20 °C
3: 4-(N,N-dimethlyamino)pyridine / dichloromethane / 20 °C
View Scheme
参考文献
Akritopoulou-Zanze, Irini; Wakefield, Brian D.; Gasiecki, Alan; Kalvin, Douglas; Johnson, Eric F.; Kovar, Peter; Djuric, Stevan W.
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 5 p. 1480 - 1483
