copper(l) iodide; potassium carbonate; L-proline in dimethyl sulfoxide
T=85°C; Buchwald-Hartwig coupling; 30 h; Large scale reaction;
参考文献
Yang, Qiang; Ulysse, Luckner G.; McLaws, Mark D.; Keefe, Daniel K.; Haney, Brian P.; Zha, Congxiang; Guzzo, Peter R.; Liu, Shuang
Organic Process Research and Development, 2012 , vol. 16, # 3 p. 499 - 506
Yang, Qiang; Ulysse, Luckner G.; McLaws, Mark D.; Keefe, Daniel K.; Haney, Brian P.; Zha, Congxiang; Guzzo, Peter R.; Liu, Shuang
Organic Process Research and Development, 2012 , vol. 16, # 3 p. 499 - 506
1: tetrahydrofuran; dichloromethane
2: phosphoric acid / 160 °C
3: copper(l) iodide; potassium carbonate; L-proline / dimethyl sulfoxide / 30 h / 85 °C / Large scale reaction
View Scheme
参考文献
Yang, Qiang; Ulysse, Luckner G.; McLaws, Mark D.; Keefe, Daniel K.; Haney, Brian P.; Zha, Congxiang; Guzzo, Peter R.; Liu, Shuang
Organic Process Research and Development, 2012 , vol. 16, # 3 p. 499 - 506
1: palladium 10 on activated carbon; hydrogen / ethanol; ethyl acetate / 2 h / 1034.32 Torr
2: potassium carbonate / acetone / 7 h / Reflux
View Scheme
参考文献
Yang, Qiang; Ulysse, Luckner G.; McLaws, Mark D.; Keefe, Daniel K.; Haney, Brian P.; Zha, Congxiang; Guzzo, Peter R.; Liu, Shuang
Organic Process Research and Development, 2012 , vol. 16, # 3 p. 499 - 506
Yang, Qiang; Ulysse, Luckner G.; McLaws, Mark D.; Keefe, Daniel K.; Haney, Brian P.; Zha, Congxiang; Guzzo, Peter R.; Liu, Shuang
Organic Process Research and Development, 2012 , vol. 16, # 3 p. 499 - 506
1: Eaton’s reagent / 80 °C
2: palladium 10 on activated carbon; hydrogen / ethanol; ethyl acetate / 2 h / 1034.32 Torr
3: potassium carbonate / acetone / 7 h / Reflux
View Scheme
参考文献
Yang, Qiang; Ulysse, Luckner G.; McLaws, Mark D.; Keefe, Daniel K.; Haney, Brian P.; Zha, Congxiang; Guzzo, Peter R.; Liu, Shuang
Organic Process Research and Development, 2012 , vol. 16, # 3 p. 499 - 506
1: phosphoric acid / 160 °C
2: copper(l) iodide; potassium carbonate; L-proline / dimethyl sulfoxide / 30 h / 85 °C / Large scale reaction
View Scheme
参考文献
Yang, Qiang; Ulysse, Luckner G.; McLaws, Mark D.; Keefe, Daniel K.; Haney, Brian P.; Zha, Congxiang; Guzzo, Peter R.; Liu, Shuang
Organic Process Research and Development, 2012 , vol. 16, # 3 p. 499 - 506
1: thionyl chloride / 60 °C
2: tetrahydrofuran; dichloromethane
3: phosphoric acid / 160 °C
4: copper(l) iodide; potassium carbonate; L-proline / dimethyl sulfoxide / 30 h / 85 °C / Large scale reaction
View Scheme
参考文献
Yang, Qiang; Ulysse, Luckner G.; McLaws, Mark D.; Keefe, Daniel K.; Haney, Brian P.; Zha, Congxiang; Guzzo, Peter R.; Liu, Shuang
Organic Process Research and Development, 2012 , vol. 16, # 3 p. 499 - 506
1: water; N,N-dimethyl-formamide; toluene
2: Eaton’s reagent / 80 °C
3: palladium 10 on activated carbon; hydrogen / ethanol; ethyl acetate / 2 h / 1034.32 Torr
4: potassium carbonate / acetone / 7 h / Reflux
View Scheme
参考文献
Yang, Qiang; Ulysse, Luckner G.; McLaws, Mark D.; Keefe, Daniel K.; Haney, Brian P.; Zha, Congxiang; Guzzo, Peter R.; Liu, Shuang
Organic Process Research and Development, 2012 , vol. 16, # 3 p. 499 - 506
