4-[2,2,2-三氟乙基-1-O-((4-甲基苯基)磺酰基)肟]苄醇叔-丁基(二甲基)硅烷基醚合成路线 （共 4 条）
反应条件
1: 86 percent / liq. NH3 / diethyl ether / 12 h / Ambient temperature 2: 91 percent / Ag2O / diethyl ether / 1 h 3: 92 percent / conc. HCl / methanol 4: 72 percent / 0.2N KOH, KMnO4 / dioxane / 2 h / Ambient temperature 5: 73 percent / N,N'-dicyclohexylcarbodiimide / dioxane; ethyl acetate / 6 h / Ambient temperature View Scheme
参考文献
Liebigs Annalen der Chemie, , # 9 p. 1510 - 1523
反应条件
1.1: NH3 / diethyl ether / -60 °C 1.2: 55 percent / triethylamine; I2 / methanol / 0 - 20 °C 2.1: 77 percent / HCl / methanol / 20 °C View Scheme
参考文献
European Journal of Organic Chemistry, , # 21 p. 4841 - 4851
反应条件
1: 86 percent / liq. NH3 / diethyl ether / 12 h / Ambient temperature 2: 91 percent / Ag2O / diethyl ether / 1 h 3: 92 percent / conc. HCl / methanol 4: 72 percent / 0.2N KOH, KMnO4 / dioxane / 2 h / Ambient temperature View Scheme
参考文献
Nassal, Michael
Liebigs Annalen der Chemie, 1983 , # 9 p. 1510 - 1523
反应条件
ammonium hydroxide in tetrahydrofuran
T=-78 - 20°C; 48 h; Sealed tube;
参考文献
Nakamoto, Kosuke; Ueno, Yoshihito
Journal of Organic Chemistry, 2014 , vol. 79, # 6 p. 2463 - 2472
