3-(4-甲基苯基)-3-(三氟甲基)二氮杂环丙烷合成路线 （共 9 条）
反应条件
1: 91 percent / Ag2O / diethyl ether / 1 h 2: 58 percent / KMnO4 / pyridine; H2O / 20 h / 50 °C 3: 73 percent / N,N'-dicyclohexylcarbodiimide / dioxane; ethyl acetate / 6 h / Ambient temperature View Scheme
参考文献
Liebigs Annalen der Chemie, , # 9 p. 1510 - 1523
反应条件
1: 65 percent / Et3N, I2 / CHCl3 / 0.25 h / Ambient temperature 2: 38 percent / KMnO4 / pyridine 3: 95 percent / cyanuric fluoride, pyridine / CH2Cl2 / 2 h / -20 - -10 °C 4: 84 percent / LiBH4 / tetrahydrofuran; methanol / 1 h / Ambient temperature View Scheme
参考文献
Journal of Labelled Compounds and Radiopharmaceuticals, , vol. 41, # 3 p. 191 - 199
反应条件
1: I2; Et3N 2: KMnO4; pyridine View Scheme
参考文献
Nassal, Michael
Liebigs Annalen der Chemie, 1983 , # 9 p. 1510 - 1523
反应条件
ammonia in diethyl ether
T=-78°C;
参考文献
Welle, Alexandre; Billard, Francois; Marchand-Brynaert, Jacqueline
Synthesis (Germany), 2012 , vol. 44, # 14 art. no. SS-2012-Z0203-OP, p. 2249 - 2254
反应条件
1: hydroxylamine
2: pyridine
3: NH3 (liquid)
View Scheme
参考文献
Wei, Shuai; Wang, Jing; Guo, Dong-Jie; Chen, Ya-Qing; Xiao, Shou-Jun
Chemistry Letters, 2006 , vol. 35, # 10 p. 1172 - 1173
反应条件
1: pyridine
2: NH3 (liquid)
View Scheme
参考文献
Wei, Shuai; Wang, Jing; Guo, Dong-Jie; Chen, Ya-Qing; Xiao, Shou-Jun
Chemistry Letters, 2006 , vol. 35, # 10 p. 1172 - 1173
反应条件
1: 83 percent / n-BuLi
2: hydroxylamine; pyridine / ethanol
3: pyridine
4: 76 percent / NH3
View Scheme
参考文献
Riber, Ditte; Venkataramana, Musturi; Sanyal, Suparna; Duvold, Tore
Journal of Medicinal Chemistry, 2006 , vol. 49, # 5 p. 1503 - 1505
反应条件
silver(l) oxide in diethyl ether
1 h;
参考文献
Nassal, Michael
Liebigs Annalen der Chemie, 1983 , # 9 p. 1510 - 1523
反应条件
N-bromosuccinmide; 2,2'-azo-bisisobutyronitrile
参考文献
Riber, Ditte; Venkataramana, Musturi; Sanyal, Suparna; Duvold, Tore
Journal of Medicinal Chemistry, 2006 , vol. 49, # 5 p. 1503 - 1505
