4-[3-(三氟甲基)-3H-双吖丙啶-3-基]苄醇合成路线 （共 26 条）
反应条件
hydrogenchloride in methanol
参考文献
Liebigs Annalen der Chemie, , # 9 p. 1510 - 1523
反应条件
diborane in tetrahydrofuran T=-5°C; 5 h;
参考文献
Journal of Medicinal Chemistry, , vol. 49, # 16 p. 4818 - 4825
反应条件
sodium tetrahydroborate in ethanol T=20°C; 4 h;
参考文献
Journal of the American Chemical Society, , vol. 128, # 47 p. 15092 - 15093
反应条件
hydrogen; triethylamine; palladium on activated charcoal in methanol T=20°C; Catalytic hydrogenation; P=760.051 Torr;
参考文献
Journal of Organic Chemistry, , vol. 65, # 21 p. 7183 - 7186
反应条件
trifluoroacetic acid in dichloromethane 2 h; Ambient temperature;
参考文献
Liebigs Annalen der Chemie, , # 9 p. 1510 - 1523
反应条件
lithium borohydride in tetrahydrofuran; methanol 1 h; Ambient temperature;
参考文献
Journal of Labelled Compounds and Radiopharmaceuticals, , vol. 41, # 3 p. 191 - 199
反应条件
1: 80 percent / TiCl4 / various solvent(s) / 1 h / 20 °C 2: 100 percent / NaBH4 / ethanol / 4 h / 20 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 128, # 47 p. 15092 - 15093
反应条件
1.1: 87 percent / imidazole / dimethylformamide / 20 °C 2.1: nBuLi / tetrahydrofuran / -30 °C 2.2: 89 percent / tetrahydrofuran / -50 °C 3.1: 60 percent / hydroxylamine hydrochloride / ethanol / 60 °C 4.1: 65 percent / N,N-DMAP; triethylamine / CH2Cl2 / 0 - 20 °C 5.1: NH3 / diethyl ether / -60 °C 5.2: 55 percent / triethylamine; I2 / methanol / 0 - 20 °C 6.1: 77 percent / HCl / methanol / 20 °C View Scheme
参考文献
European Journal of Organic Chemistry, , # 21 p. 4841 - 4851
反应条件
1.1: 60 percent / hydroxylamine hydrochloride / ethanol / 60 °C 2.1: 65 percent / N,N-DMAP; triethylamine / CH2Cl2 / 0 - 20 °C 3.1: NH3 / diethyl ether / -60 °C 3.2: 55 percent / triethylamine; I2 / methanol / 0 - 20 °C 4.1: 77 percent / HCl / methanol / 20 °C View Scheme
参考文献
European Journal of Organic Chemistry, , # 21 p. 4841 - 4851
反应条件
1.1: nBuLi / tetrahydrofuran / -30 °C 1.2: 89 percent / tetrahydrofuran / -50 °C 2.1: 60 percent / hydroxylamine hydrochloride / ethanol / 60 °C 3.1: 65 percent / N,N-DMAP; triethylamine / CH2Cl2 / 0 - 20 °C 4.1: NH3 / diethyl ether / -60 °C 4.2: 55 percent / triethylamine; I2 / methanol / 0 - 20 °C 5.1: 77 percent / HCl / methanol / 20 °C View Scheme
参考文献
European Journal of Organic Chemistry, , # 21 p. 4841 - 4851
