4-[3-(三氟甲基)-3H-双吖丙啶-3-基]苄醇合成路线 （共 26 条）
反应条件
1.1: 65 percent / N,N-DMAP; triethylamine / CH2Cl2 / 0 - 20 °C 2.1: NH3 / diethyl ether / -60 °C 2.2: 55 percent / triethylamine; I2 / methanol / 0 - 20 °C 3.1: 77 percent / HCl / methanol / 20 °C View Scheme
参考文献
European Journal of Organic Chemistry, , # 21 p. 4841 - 4851
反应条件
1.1: NH3 / diethyl ether / -60 °C 1.2: 55 percent / triethylamine; I2 / methanol / 0 - 20 °C 2.1: 77 percent / HCl / methanol / 20 °C View Scheme
参考文献
European Journal of Organic Chemistry, , # 21 p. 4841 - 4851
反应条件
1: 91 percent / Ag2O / diethyl ether / 1 h 2: 92 percent / conc. HCl / methanol View Scheme
参考文献
Liebigs Annalen der Chemie, , # 9 p. 1510 - 1523
反应条件
1: 38 percent / KMnO4 / pyridine 2: 95 percent / cyanuric fluoride, pyridine / CH2Cl2 / 2 h / -20 - -10 °C 3: 84 percent / LiBH4 / tetrahydrofuran; methanol / 1 h / Ambient temperature View Scheme
参考文献
Journal of Labelled Compounds and Radiopharmaceuticals, , vol. 41, # 3 p. 191 - 199
反应条件
1: 65 percent / Et3N, I2 / CHCl3 / 0.25 h / Ambient temperature 2: 38 percent / KMnO4 / pyridine 3: 95 percent / cyanuric fluoride, pyridine / CH2Cl2 / 2 h / -20 - -10 °C 4: 84 percent / LiBH4 / tetrahydrofuran; methanol / 1 h / Ambient temperature View Scheme
参考文献
Journal of Labelled Compounds and Radiopharmaceuticals, , vol. 41, # 3 p. 191 - 199
反应条件
1: 1) n-BuLi / 1) hexane, ether, -30 to 0 deg C in 2 h, 2) ether, -50 deg C, 3 h 2: 57 percent / NH3OHCl, NaOH / ethanol / 16 h / Heating 3: 87 percent / pyridine / 3 h / Heating 4: 80 percent / NH3 / diethyl ether / 12 h / Ambient temperature 5: 92 percent / Ag2O / diethyl ether / 1 h 6: 86 percent / TFA / CH2Cl2 / 2 h / Ambient temperature View Scheme
参考文献
Liebigs Annalen der Chemie, , # 9 p. 1510 - 1523
反应条件
1: 57 percent / NH3OHCl, NaOH / ethanol / 16 h / Heating 2: 87 percent / pyridine / 3 h / Heating 3: 80 percent / NH3 / diethyl ether / 12 h / Ambient temperature 4: 92 percent / Ag2O / diethyl ether / 1 h 5: 86 percent / TFA / CH2Cl2 / 2 h / Ambient temperature View Scheme
参考文献
Liebigs Annalen der Chemie, , # 9 p. 1510 - 1523
反应条件
1: 92 percent / Ag2O / diethyl ether / 1 h 2: 86 percent / TFA / CH2Cl2 / 2 h / Ambient temperature View Scheme
参考文献
Liebigs Annalen der Chemie, , # 9 p. 1510 - 1523
反应条件
1: 87 percent / pyridine / 3 h / Heating 2: 80 percent / NH3 / diethyl ether / 12 h / Ambient temperature 3: 92 percent / Ag2O / diethyl ether / 1 h 4: 86 percent / TFA / CH2Cl2 / 2 h / Ambient temperature View Scheme
参考文献
Liebigs Annalen der Chemie, , # 9 p. 1510 - 1523
反应条件
1: 80 percent / NH3 / diethyl ether / 12 h / Ambient temperature 2: 92 percent / Ag2O / diethyl ether / 1 h 3: 86 percent / TFA / CH2Cl2 / 2 h / Ambient temperature View Scheme
参考文献
Liebigs Annalen der Chemie, , # 9 p. 1510 - 1523
