4-[3-(三氟甲基)二氮杂环丙烯-3-基]苯甲酸 N-羟基琥珀酰亚胺酯合成路线 （共 21 条）
反应条件
1: 92 percent / Ag2O / diethyl ether / 1 h 2: 86 percent / TFA / CH2Cl2 / 2 h / Ambient temperature 3: 72 percent / 0.2N KOH, KMnO4 / dioxane / 2 h / Ambient temperature 4: 73 percent / N,N'-dicyclohexylcarbodiimide / dioxane; ethyl acetate / 6 h / Ambient temperature View Scheme
参考文献
Liebigs Annalen der Chemie, , # 9 p. 1510 - 1523
反应条件
1: 93 percent / NH3OHCl, NaOH / ethanol / 16 h / Heating 2: 70 percent / pyridine / 3 h / Heating 3: 86 percent / liq. NH3 / diethyl ether / 12 h / Ambient temperature 4: 91 percent / Ag2O / diethyl ether / 1 h 5: 92 percent / conc. HCl / methanol 6: 72 percent / 0.2N KOH, KMnO4 / dioxane / 2 h / Ambient temperature 7: 73 percent / N,N'-dicyclohexylcarbodiimide / dioxane; ethyl acetate / 6 h / Ambient temperature View Scheme
参考文献
Liebigs Annalen der Chemie, , # 9 p. 1510 - 1523
反应条件
1: 92 percent / conc. HCl / methanol 2: 72 percent / 0.2N KOH, KMnO4 / dioxane / 2 h / Ambient temperature 3: 73 percent / N,N'-dicyclohexylcarbodiimide / dioxane; ethyl acetate / 6 h / Ambient temperature View Scheme
参考文献
Liebigs Annalen der Chemie, , # 9 p. 1510 - 1523
反应条件
1: 91 percent / Ag2O / diethyl ether / 1 h 2: 92 percent / conc. HCl / methanol 3: 72 percent / 0.2N KOH, KMnO4 / dioxane / 2 h / Ambient temperature 4: 73 percent / N,N'-dicyclohexylcarbodiimide / dioxane; ethyl acetate / 6 h / Ambient temperature View Scheme
参考文献
Liebigs Annalen der Chemie, , # 9 p. 1510 - 1523
反应条件
1: 92 percent / pyridine / 3 h / Heating 2: 91 percent / liq. NH3 / diethyl ether / 12 h / Ambient temperature 3: 91 percent / Ag2O / diethyl ether / 1 h 4: 58 percent / KMnO4 / pyridine; H2O / 20 h / 50 °C 5: 73 percent / N,N'-dicyclohexylcarbodiimide / dioxane; ethyl acetate / 6 h / Ambient temperature View Scheme
参考文献
Liebigs Annalen der Chemie, , # 9 p. 1510 - 1523
反应条件
1: 72 percent / 0.2N KOH, KMnO4 / dioxane / 2 h / Ambient temperature 2: 73 percent / N,N'-dicyclohexylcarbodiimide / dioxane; ethyl acetate / 6 h / Ambient temperature View Scheme
参考文献
Liebigs Annalen der Chemie, , # 9 p. 1510 - 1523
反应条件
1: 87 percent / pyridine / 3 h / Heating 2: 80 percent / NH3 / diethyl ether / 12 h / Ambient temperature 3: 92 percent / Ag2O / diethyl ether / 1 h 4: 86 percent / TFA / CH2Cl2 / 2 h / Ambient temperature 5: 72 percent / 0.2N KOH, KMnO4 / dioxane / 2 h / Ambient temperature 6: 73 percent / N,N'-dicyclohexylcarbodiimide / dioxane; ethyl acetate / 6 h / Ambient temperature View Scheme
参考文献
Liebigs Annalen der Chemie, , # 9 p. 1510 - 1523
反应条件
1: 70 percent / pyridine / 3 h / Heating 2: 86 percent / liq. NH3 / diethyl ether / 12 h / Ambient temperature 3: 91 percent / Ag2O / diethyl ether / 1 h 4: 92 percent / conc. HCl / methanol 5: 72 percent / 0.2N KOH, KMnO4 / dioxane / 2 h / Ambient temperature 6: 73 percent / N,N'-dicyclohexylcarbodiimide / dioxane; ethyl acetate / 6 h / Ambient temperature View Scheme
参考文献
Liebigs Annalen der Chemie, , # 9 p. 1510 - 1523
反应条件
1: 91 percent / liq. NH3 / diethyl ether / 12 h / Ambient temperature 2: 91 percent / Ag2O / diethyl ether / 1 h 3: 58 percent / KMnO4 / pyridine; H2O / 20 h / 50 °C 4: 73 percent / N,N'-dicyclohexylcarbodiimide / dioxane; ethyl acetate / 6 h / Ambient temperature View Scheme
参考文献
Liebigs Annalen der Chemie, , # 9 p. 1510 - 1523
反应条件
1: 80 percent / NH3 / diethyl ether / 12 h / Ambient temperature 2: 92 percent / Ag2O / diethyl ether / 1 h 3: 86 percent / TFA / CH2Cl2 / 2 h / Ambient temperature 4: 72 percent / 0.2N KOH, KMnO4 / dioxane / 2 h / Ambient temperature 5: 73 percent / N,N'-dicyclohexylcarbodiimide / dioxane; ethyl acetate / 6 h / Ambient temperature View Scheme
参考文献
Liebigs Annalen der Chemie, , # 9 p. 1510 - 1523
