(S)-1-(2,6-二氯-3-氟苯基)乙醇合成路线 （共 6 条）
反应条件
1: With sodium methylate in methanol T=0 - 20°C; 4 h; 2: With sodium acetate; acetic acid in water pH=7;
参考文献
PFIZER INC.
Patent: WO2006/21881 A2, 2006 ;
Location in patent: Page/Page column 59 ;
WO 2006/021881 A2
反应条件
4-(N,N-dimethlyamino)pyridine; 1-(tert-butoxycarbonyl)-L-proline; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in 1,2-dichloro-ethane T=0 - 20°C;
参考文献
XCOVERY HOLDING COMPANY, LLC; LIANG, Congxin
Patent: WO2012/48258 A2, 2012 ;
Location in patent: Page/Page column 31-32 ;
WO 2012/048258 A2
反应条件
1: sodium hydroxide / aq. phosphate buffer / 20 h / 20 °C / pH 7.0 / |Enzymatic reaction 2: sodium methylate / methanol / 4 h / 0 - 20 °C / |Inert atmosphere View Scheme
参考文献
WO2013/17989 A1, ;
WO 2013/017989 A1
反应条件
1: pyridine / 3 h / 20 °C / |Inert atmosphere 2: N,N-dimethyl-formamide / 12 h / 100 °C / |Inert atmosphere 3: sodium methylate / methanol / 4 h / 0 - 20 °C / |Inert atmosphere View Scheme
参考文献
WO2013/17989 A1, ;
WO 2013/017989 A1
反应条件
1: N,N-dimethyl-formamide / 12 h / 100 °C / |Inert atmosphere 2: sodium methylate / methanol / 4 h / 0 - 20 °C / |Inert atmosphere View Scheme
参考文献
WO2013/17989 A1, ;
WO 2013/017989 A1
反应条件
di-isopropyl azodicarboxylate; triphenylphosphine in tetrahydrofuran
T=0 - 20°C; 13 h;
参考文献
PFIZER INC.
Patent: WO2006/21886 A1, 2006 ;
Location in patent: Page/Page column 51 ;
WO 2006/021886 A1
