1: 4-bromo(1H)-pyrazole With sodium hydride in N,N-dimethyl-formamide T=0°C; 1 h; Inert atmosphere; 2: 4-methanesulfonyloxy-piperidine-1-carboxylic acid tert-butyl ester in N,N-dimethyl-formamide T=100°C; 1 h; Inert atmosphere;

1: triethylamine / dichloromethane / 3 h / 0 - 20 °C 2: sodium hydride / N,N-dimethyl-formamide; mineral oil / 12 h / 80 °C View Scheme

1: triethylamine / dichloromethane / 1 h / 0 - 20 °C 2: triethylamine / dichloromethane / 3 h / 0 - 20 °C 3: sodium hydride / N,N-dimethyl-formamide; mineral oil / 12 h / 80 °C View Scheme

1: triethylamine / dichloromethane / 1 h / 0 - 20 °C 2: triethylamine / dichloromethane / 3 h / 0 - 20 °C 3: sodium hydride / N,N-dimethyl-formamide; mineral oil / 12 h / 80 °C View Scheme

1: tert-butyl 4-(4-bromo-1H-pyrazol-1-yl)piperidine-1-carboxylate With isopropylmagnesium chloride; lithium chloride in tetrahydrofuran T=20 - 30°C; 12 h; 2: 2-isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane in tetrahydrofuran T=20 - 30°C; 6 h;

(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate in 1,4-dioxane T=90°C; Inert atmosphere;

1: tert-butyl 4-(4-bromo-1H-pyrazol-1-yl)piperidine-1-carboxylate With isopropylmagnesium chloride; lithium chloride in tetrahydrofuran T=20 - 30°C; 12 h; 2: MeOB(pin) in tetrahydrofuran T=20 - 30°C; 6 h;