sulfuric acid in acetic anhydride Heating;

1: 1) LDA / 1) THF, -40 deg C, 1h, 2a) -40 deg C, 1 h, 2b) up tu 0 deg C, 3h 2: 85 percent / H2SO4 / acetic anhydride / Heating View Scheme

1: 1) LDA / 1) THF, -40 deg C, 1h, 2a) -40 deg C, 1 h, 2b) up tu 0 deg C, 3h 2: 85 percent / H2SO4 / acetic anhydride / Heating View Scheme

1: 1) lithium diisopropylamide / 1) THF, 0 deg C, 2 h, 2) THF, 0 deg C, 2 h, then r.t. overnight 2: H2SO4, acetic anhydride / Ambient temperature 3: 5.5 g / 20percent NaOH / 40 h / Heating View Scheme

1: 100 percent / dimethylformamide / 2.5 h / 55 °C 2: 96 percent / 2-methyl-propan-2-ol / 3.5 h / 70 °C 3: 1) lithium diisopropylamide / 1) THF, -30 deg C, 2.5 h, 2) THF, -30 deg C, 2 h, then to O deg C during 1 h 4: 93 percent / H2SO4, acetic anhydride 5: 5.5 g / 20percent NaOH / 40 h / Heating View Scheme

1: 96 percent / 2-methyl-propan-2-ol / 3.5 h / 70 °C 2: 1) lithium diisopropylamide / 1) THF, -30 deg C, 2.5 h, 2) THF, -30 deg C, 2 h, then to O deg C during 1 h 3: 93 percent / H2SO4, acetic anhydride 4: 5.5 g / 20percent NaOH / 40 h / Heating View Scheme

sodium hydroxide 40 h; Heating;

1: H2SO4, acetic anhydride / Ambient temperature 2: 5.5 g / 20percent NaOH / 40 h / Heating View Scheme