2,3-二氢-5-苯并呋喃乙醇合成路线 （共 8 条）
反应条件
1: With borane-THF in tetrahydrofuran T=0 - 20°C; 20 h; 2: With water in tetrahydrofuran
参考文献
ARGENTA DISCOVERY LTD.
Patent: WO2008/96093 A1, 2008 ;
Location in patent: Page/Page column 29 ;
WO 2008/096093 A1
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran T=0 - 20°C; 1 h; 2: With water in tetrahydrofuran
参考文献
AUSPEX PHARMACEUTICALS, INC.
Patent: US2009/5431 A1, 2009 ;
Location in patent: Page/Page column 31 ;
US 20090005431 A1
反应条件
sodium hydroxide; sodium tetrahydroborate; water; sodium carbonate in toluene T=5 - 20°C; pH=9.8 - 10.2; 1.75 - 2 h; Product distribution / selectivity;
参考文献
WO2007/76157 A2, ;
Page/Page column 48 ;
反应条件
1: With sodium tetrahydroborate in methanol; tert-butyl alcohol 6.5 h; Heating / reflux; 2: With water Product distribution / selectivity;
参考文献
WO2007/76157 A2, ;
Page/Page column 43-44 ;
反应条件
thionyl chloride in toluene T=25 - 60°C; 14 h;
参考文献
TEVA PHARMACEUTICAL FINE CHEMICALS S.R.L.; TEVA PHARMACEUTICALS USA, INC.
Patent: WO2007/76157 A2, 2007 ;
Location in patent: Page/Page column 44 ;
反应条件
triethylamine in tetrahydrofuran; diethyl ether; water
参考文献
AUROBINDO PHARMA LIMITED; GARIMELLA, Narayan, K., A., S., S.; SANAPUREDDY, Jagan, Mohan, Reddy; KAKI, Gowrisankar, Rao; KATUROJU, Srinivasa, Chary; ISLAM, Aminul; MEENAKSHISUNDERAM, Sivakumaran
Patent: WO2011/70419 A1, 2011 ;
Location in patent: Page/Page column 10-11 ;
反应条件
1.1: triethylamine / dichloromethane / 0 - 25 °C / Inert atmosphere 2.1: potassium carbonate / acetonitrile / 25 - 70 °C / Inert atmosphere 2.2: 5 - 30 °C / pH 2 - 9 View Scheme
参考文献
AUROBINDO PHARMA LIMITED; GARIMELLA, Narayan, K., A., S., S.; SANAPUREDDY, Jagan, Mohan, Reddy; KAKI, Gowrisankar, Rao; KATUROJU, Srinivasa, Chary; ISLAM, Aminul; MEENAKSHISUNDERAM, Sivakumaran
Patent: WO2011/70419 A1, 2011 ;
反应条件
carbon tetrabromide; triphenylphosphine in dichloromethane T=20°C; 63 h;
参考文献
ARGENTA DISCOVERY LTD.
Patent: WO2008/96093 A1, 2008 ;
Location in patent: Page/Page column 29 ;
WO 2008/096093 A1
