6-三氟甲基-1H-吲唑-3-羧酸甲酯合成路线 （共 3 条）
反应条件
1: potassium tert-butylate / tert-butyl alcohol / Reflux
2: dimethyl sulfoxide; sodium chloride / water / 120 °C
3: hydrogen / 5 Pd(II)/C(eggshell) / toluene / 20 °C / 760.05 Torr
4: tert.-butylnitrite; acetic acid / 2.17 h / 90 - 95 °C / Cooling with ice
View Scheme
参考文献
UNIVERSITY OF KANSAS; GEORGE, Ingrid, Gunda; TASH, Joseph, S.; CHAKRSALI, Ramappa; JAKKARAJ, Sudhakar, R.; CALVET, James, P.
Patent: WO2011/5759 A2, 2011 ;
反应条件
1: dimethyl sulfoxide; sodium chloride / water / 120 °C
2: hydrogen / 5 Pd(II)/C(eggshell) / toluene / 20 °C / 760.05 Torr
3: tert.-butylnitrite; acetic acid / 2.17 h / 90 - 95 °C / Cooling with ice
View Scheme
参考文献
UNIVERSITY OF KANSAS; GEORGE, Ingrid, Gunda; TASH, Joseph, S.; CHAKRSALI, Ramappa; JAKKARAJ, Sudhakar, R.; CALVET, James, P.
Patent: WO2011/5759 A2, 2011 ;
反应条件
1: hydrogen / 5 Pd(II)/C(eggshell) / toluene / 20 °C / 760.05 Torr
2: tert.-butylnitrite; acetic acid / 2.17 h / 90 - 95 °C / Cooling with ice
View Scheme
参考文献
UNIVERSITY OF KANSAS; GEORGE, Ingrid, Gunda; TASH, Joseph, S.; CHAKRSALI, Ramappa; JAKKARAJ, Sudhakar, R.; CALVET, James, P.
Patent: WO2011/5759 A2, 2011 ;
