反应条件
1: 4-butylaniline hydrochloride / 2-methoxy-ethanol / Heating 2: 96 percent / phosphoryl chloride, N,N-dimethylaniline / 0.17 h / Heating 3: 1.) NaH / 1.) MeCN, RT, 20 min, 2.) MeCN, RT, 1 h 4: 76 percent / MeONa / methanol / 24 h 5: 77 percent / K2CO3, H2 / 10percent Pd/C / ethanol; H2O / 4 h / 2585.7 Torr View Scheme
参考文献
Wright, George E.; Dudycz, Lech W.; Kazimierczuk, Zygmunt; Brown, Neal C.; Khan, Naseema N.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 1 p. 109 - 116
