5-苄氧基-2-(1-哌嗪基)嘧啶合成路线 （共 3 条）
反应条件
copper(l) iodide; 1,10-phenanthroline; caesium carbonate in toluene T=110°C; 24 h; Inert atmosphere;
参考文献
BAYER PHARMA AKTIENGESELLSCHAFT; SCHMITT-WILLICH, Heribert; HEINRICH, Tobias; BROCKSCHNIEDER, Damian
Patent: WO2011/110488 A1, 2011 ;
Location in patent: Page/Page column 19 ;
反应条件
in ethanol 1.) ice bath, 2.) room temperature;
参考文献
Ishizumi; Kojima; Antoku
Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 9 p. 2288 - 2300
反应条件
1: 89.7 percent / K2CO3 / dimethylformamide / 1 h / 90 - 100 °C 2: 50.6 percent / ethanol / 1.) ice bath, 2.) room temperature View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 39, # 9 p. 2288 - 2300
