2-羟基-4,5-二甲氧基苯甲酸苯酯合成路线 (共 4 条)
反应条件
sulfuric acid in methanol; argon; toluene
参考文献
ZERIA PHARMACEUTICAL CO., LTD.
Patent: EP1792888 A1, 2007 ;
反应条件
sulfuric acid in toluene 2.5 h; Heating / reflux; Product distribution / selectivity;
参考文献
Zeria Pharmaceutical Co., LTD; Nakao, Ryu
Patent: US2013/253222 A1, 2013 ;
Location in patent: Paragraph 0039 ;
反应条件
thionyl chloride in methanol; anhydrous xylene
参考文献
ZERIA PHARMACEUTICAL CO., LTD.
Patent: WO2006/22252 A1, 2006 ;
Location in patent: Page/Page column 10 ;
反应条件
1: bromine; hydrogenchloride / water / 3 h / 20 - 30 °C 2: sodium carbonate; copper(II) sulfate; pyridine; water / 1 h / 80 - 100 °C 3: sulfuric acid / toluene / 2.5 h / |Inert atmosphere; |Reflux View Scheme