4-(3-丁烯-1-基)-噻唑合成路线 (共 1 条)
反应条件
1: formamide With diphosphorus pentasulfide in ethylene glycol dimethyl ether
T=65°C; 0.166667 h;
2: 1-bromohex-5-en-2-one in ethylene glycol dimethyl ether
T=65 - 110°C; 1.66667 h;
3: With hydrogenchloride; dihydrogen peroxide
more than 3 stages;
参考文献
ACTELION PHARMACEUTICALS LTD.
Patent: WO2006/21402 A1, 2006 ;
Location in patent: Page/Page column 31-32 ;
WO 2006/021402 A1