1: TsOH 2: O2, PdCl2, CuCl / dimethylformamide; H2O 3: 50 percent / LDA, HMPA / tetrahydrofuran; hexane / 1.) -78 deg C, 30 min. 2.) 0 deg C, 30 min 4: HCl / acetone / 0.5 h / 0 °C 5: NaH / tetrahydrofuran / 12 h / Heating View Scheme

1: 50 percent / LDA, HMPA / tetrahydrofuran; hexane / 1.) -78 deg C, 30 min. 2.) 0 deg C, 30 min 2: HCl / acetone / 0.5 h / 0 °C 3: NaH / tetrahydrofuran / 12 h / Heating View Scheme

1: HCl / acetone / 0.5 h / 0 °C 2: NaH / tetrahydrofuran / 12 h / Heating View Scheme