2-溴-4-甲基苯甲酸甲酯合成路线 （共 12 条）
反应条件
sulfuric acid 18 h; Heating / reflux;
参考文献
3-V BIOSCIENCES, INC.; OSLOB, Johan D.; MCDOWELL, Robert S.; JOHNSON, Russell; YANG, Hanbiao; EVANCHIK, Marc; ZAHARIA, Cristiana A.; CAI, Haiying; HU, Lily W.
Patent: WO2014/8197 A1, 2014 ;
Location in patent: Page/Page column 163 ;
反应条件
sulfuric acid in methanol; ethyl acetate
参考文献
Anacor Pharmaceuticals, Inc.; Eli Lilly and Company; AKAMA, Tsutomu; Balko, Terry William; Defauw, Jean Marie; Plattner, Jacob J.; White, William Hunter; Winkle, Joseph Raymond; Zhang, Yong-Kang; Zhou, Yasheen
Patent: US2013/131017 A1, 2013 ;
Location in patent: Paragraph 0404 ;
反应条件
in methanol; diethyl ether; toluene 2 h; Inert atmosphereSchlenk technique;
参考文献
Dydio, Pawel; Reek, Joost N. H.
Angewandte Chemie - International Edition, 2013 , vol. 52, # 14 p. 3878 - 3882
Angew. Chem., 2013 , vol. 125, # 14 p. 4132
反应条件
1: water; aqueous sodium tetracyanocuprate (I)-solution / Diazotization 2: aqueous sulfuric acid View Scheme
参考文献
Journal of the Chemical Society, , p. 1231,1233
反应条件
1: aqueous sulfuric acid View Scheme
参考文献
Journal of the Chemical Society, , p. 1231,1233
参考文献
Journal of the Chemical Society, , p. 1231,1233
反应条件
hydrazine hydrate in ethanol 24 h; HeatingReflux;
参考文献
OSLO UNIVERSITY HOSPITAL HF; HOLSWORTH, Dan; WAALER, Jo; MACHON, Ondrej; KRAUSS, Stefan; GOLDING, Louise
Patent: WO2010/139966 A1, 2010 ;
Location in patent: Page/Page column 125 ;
反应条件
N-bromosuccinmide; dibenzoyl peroxide in tetrachloromethane 1 h; Heating / reflux;
参考文献
WYETH
Patent: US2005/70584 A1, 2005 ;
Location in patent: Page/Page column 24 ;
反应条件
1: potassium permanganate; 18-crown-6 ether / water; tert-butyl alcohol / 2.33 h / 20 - 75 °C 2: thionyl chloride / methanol / 5 h / |Reflux View Scheme
参考文献
Anacor Pharmaceuticals, Inc.; Eli Lilly and Company; AKAMA, Tsutomu; Balko, Terry William; Defauw, Jean Marie; Plattner, Jacob J.; White, William Hunter; Winkle, Joseph Raymond; Zhang, Yong-Kang; Zhou, Yasheen
Patent: US2013/131017 A1, 2013 ;
反应条件
potassium permanganate; 18-crown-6 ether in water; tert-butyl alcohol
T=20 - 75°C; 2.33 h;
参考文献
Anacor Pharmaceuticals, Inc.; Eli Lilly and Company; AKAMA, Tsutomu; Balko, Terry William; Defauw, Jean Marie; Plattner, Jacob J.; White, William Hunter; Winkle, Joseph Raymond; Zhang, Yong-Kang; Zhou, Yasheen
Patent: US2013/131017 A1, 2013 ;
Location in patent: Paragraph 0361; 0556 ;
