反应条件
1.1: 73 percent / MsCl; Et3N; DMAP / CH2Cl2 / 2.5 h / Heating
2.1: (DHQD)2AQN; K2OsO2(OH)4; K3Fe(CN)6 / K2CO3; MeSO2NH2 / 2-methyl-propan-2-ol; H2O / 24 h / 2 °C
3.1: Et3N / CH2Cl2 / 0.5 h / -78 °C
4.1: 88 percent / KHMDS; 18-crown-6/MeCN complex / tetrahydrofuran; toluene / 2 h / 0 °C
5.1: 95 percent / Et3N / CH2Cl2 / 0.5 h / -30 °C
6.1: 90 percent / DIBAL-H / toluene; hexane / 0.33 h / -20 °C
7.1: Dess-Martin periodinane / CH2Cl2 / 1 h / 25 °C
8.1: PPh3 / CH2Cl2 / 0.08 h / 0 °C
8.2: 3.90 g / Et3N / CH2Cl2 / 0.17 h / 0 °C
9.1: 95 percent / DDQ / CH2Cl2; H2O / 1.5 h / 25 °C
10.1: 93 percent / i-Pr2NEt; DMAP / CH2Cl2 / 0.5 h / 25 °C
11.1: 84 percent / Bu3SnH; (Ph3P)4Pd / benzene / 2.5 h / 25 °C
12.1: 83 percent / iPr2NEt; 1-methyl-2-pyrrolidinone; (CH3CN)2PdCl2 / 2 h / 25 °C
13.1: 98 percent / DIBAL-H / toluene / 0.08 h / -78 °C
14.1: 97 percent / Dess-Martin periodinane / CH2Cl2 / 0.5 h / 25 °C
15.1: BuLi / toluene; hexane / 0.25 h / -78 °C
15.2: toluene; hexane / 0.25 h / -78 °C
16.1: 140 mg / NaHCO3; Dess-Martin periodinane / CH2Cl2 / 1 h / 25 °C
17.1: 75 percent / t-BuOK / toluene; tetrahydrofuran / 2 h / 0 °C
18.1: CeCl3; t-BuLi / tetrahydrofuran; diethyl ether / 0.17 h / -78 °C
18.2: tetrahydrofuran; diethyl ether; toluene / 0.08 h / -78 °C
19.1: PPTS / 2 h / 25 °C
20.1: Et3N / DMAP / CH2Cl2 / 1 h
21.1: 2,6-lutidine / CH2Cl2 / 0.75 h / -20 °C
22.1: aq. HCl / acetone / 2 h / -15 - 0 °C
23.1: 40 percent / Ag2CO3-Celite / benzene / 2 h / 80 °C
24.1: PCl3; pyridine / 0.25 h / 25 °C
24.2: 1 h
25.1: 3.9 mg / aq. H2O2 / CH2Cl2; pyridine / 0.5 h
26.1: aq. HF / acetonitrile / 0.25 h / 25 °C
26.2: aq. HF; pyridine / acetonitrile / 168000 h
View Scheme
参考文献
Boger; Ichikawa; Zhong
Journal of the American Chemical Society, 2001 , vol. 123, # 18 p. 4161 - 4167
