4-(环己基氨基)-3-硝基苯甲酸乙酯合成路线 （共 6 条）
反应条件
hydrogen; palladium(II) hydroxide/carbon in methanol P=760.051 Torr; 72 h;
参考文献
Boehringer Ingelheim (Canada) Ltd.
Patent: US2003/236251 A1, 2003 ;
Location in patent: Page 20 ;
反应条件
sodium dithionite in ethanol T=90°C; 3 h; Inert atmosphere;
参考文献
Oda, Shinichi; Shimizu, Hideki; Aoyama, Yasunori; Ueki, Tatsuo; Shimizu, Sumio; Osato, Hiroshi; Takeuchi, Yoshiyuki
Organic Process Research and Development, 2012 , vol. 16, # 1 p. 96 - 101
反应条件
in dimethyl sulfoxide
T=60°C; 5 h;
参考文献
Boehringer Ingelheim (Canada) Ltd.
Patent: US2003/236251 A1, 2003 ;
Location in patent: Page 19-20 ;
反应条件
potassium carbonate in dimethyl sulfoxide
T=20°C;
参考文献
Ishida, Tomio; Suzuki, Takayoshi; Hirashima, Shintaro; Mizutani, Kenji; Yoshida, Atsuhito; Ando, Izuru; Ikeda, Satoru; Adachi, Tsuyoshi; Hashimoto, Hiromasa
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 7 p. 1859 - 1863
反应条件
1: 97 percent / H2SO4
2: K2CO3 / dimethylsulfoxide / 20 °C
View Scheme
参考文献
Ishida, Tomio; Suzuki, Takayoshi; Hirashima, Shintaro; Mizutani, Kenji; Yoshida, Atsuhito; Ando, Izuru; Ikeda, Satoru; Adachi, Tsuyoshi; Hashimoto, Hiromasa
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 7 p. 1859 - 1863
反应条件
1.1: sodium dithionite / ethanol; dimethyl sulfoxide / 2.5 h / 90 °C / Inert atmosphere
2.1: lithium hydroxide hydrate / tetrahydrofuran; methanol; water / 1 h / 30 °C / Inert atmosphere
2.2: 0 °C / pH 4 / Inert atmosphere
View Scheme
参考文献
Oda, Shinichi; Shimizu, Hideki; Aoyama, Yasunori; Ueki, Tatsuo; Shimizu, Sumio; Osato, Hiroshi; Takeuchi, Yoshiyuki
Organic Process Research and Development, 2012 , vol. 16, # 1 p. 96 - 101
