3-氰嘧啶-4-硼酸频哪酯合成路线 （共 5 条）
反应条件
1: pyridine-3-carbonitrile With tri-isopropoxy-borane; 2,2,6,6-tetramethylpiperidinyl-lithium in tetrahydrofuran; hexane T=-78 - 20°C; Inert atmosphere; 2: With acetic acid in tetrahydrofuran; hexane T=20°C; Inert atmosphere; 3: 2,3-dimethylbutane-2,3-diol in tetrahydrofuran; hexane T=20°C; 2 h; Inert atmosphere;
参考文献
Rochais, Christophe; Yougnia, Rodrigue; Cailly, Thomas; Sopkova-De Oliveira Santos, Jana; Rault, Sylvain; Dallemagne, Patrick
Tetrahedron, 2011 , vol. 67, # 32 p. 5806 - 5810
反应条件
magnesium sulfate in toluene T=20°C; 12 h;
参考文献
Cailly, Thomas; Fabis, Frederic; Bouillon, Alexandre; Lemaitre, Stephane; Sopkova, Jana; De Santos, Olivieira; Rault, Sylvain
Synlett, 2006 , # 1 art. no. G33905ST, p. 53 - 56
反应条件
1.1: 2,2,6,6-tetramethylpiperidine; n-BuLi / tetrahydrofuran / 0.5 h / -80 °C 1.2: tetrahydrofuran / -80 - 20 °C 2.1: aq. HCl / pH 6 3.1: 78 percent / MgSO4 / toluene / 12 h / 20 °C View Scheme
参考文献
Synlett, , # 1 art. no. G33905ST, p. 53 - 56
反应条件
1: 72 percent / CsF / Pd(PPh3)4; CuI / dimethylformamide / 0.5 h / 150 °C / microwave irradiation
2: 78 percent / KOH / methanol / 0.5 h / 150 °C / microwave irradiation
View Scheme
参考文献
Cailly, Thomas; Fabis, Frederic; Legay, Remi; Oulyadi, Hassan; Rault, Sylvain
Tetrahedron, 2007 , vol. 63, # 1 p. 71 - 76
反应条件
1: 72 percent / CsF / Pd(PPh3)4; CuI / dimethylformamide / 0.5 h / 150 °C / microwave irradiation
2: 78 percent / KOH / methanol / 0.5 h / 150 °C / microwave irradiation
3: 76 percent / POCl3 / 12 h / 100 °C
View Scheme
参考文献
Cailly, Thomas; Fabis, Frederic; Legay, Remi; Oulyadi, Hassan; Rault, Sylvain
Tetrahedron, 2007 , vol. 63, # 1 p. 71 - 76
