5-氟咪唑并[1,2-a]吡啶-2-甲醛合成路线 （共 4 条）
反应条件
water; sodium acetate in ethanol T=60°C; 12 h;
参考文献
Gudmundsson, Kristjan S.; Boggs, Sharon D.; Catalano, John G.; Svolto, Angilique; Spaltenstein, Andrew; Thomson, Michael; Wheelan, Pat; Jenkinson, Stephen
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 22 p. 6399 - 6403
反应条件
1: in ethylene glycol dimethyl ether T=20°C; 15 h; 2: With ethanol 4 h; Heating / reflux; 3: With calcium carbonate in water 2 h; Heating / reflux;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2006/96444 A2, 2006 ;
Location in patent: Page/Page column 44-45 ;
WO 2006/096444 A2
反应条件
1: in ethylene glycol dimethyl ether T=20°C; 15 h; 2: in ethanol 4 h; Heating / reflux; 3: With calcium carbonate in water 2 h; Heating / reflux; Product distribution / selectivity;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2007/87549 A2, 2007 ;
Location in patent: Page/Page column 38-39 ;
WO 2007/087549 A2
反应条件
1: With sodium tetrahydroborate in methanol
T=0 - 20°C; 2 h;
2: With water in methanol
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2006/36816 A2, 2006 ;
Location in patent: Page/Page column 61 ;
WO 2006/036816 A2
