6-氯-3-甲基-2-吡啶羧酸甲酯合成路线 （共 7 条）
反应条件
trichlorophosphate in 1,2-dichloro-ethane 4 h; Reflux;
参考文献
Lim, Chae Jo; Kim, Ji Young; Lee, Byung Ho; Oh, Kwang-Seok; Yi, Kyu Yang
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 6 p. 1736 - 1739
反应条件
methanol in tetrahydrofuran T=20°C; 2 h;
参考文献
WO2009/155156 A1, ;
Page/Page column 63 ;
WO 2009/155156 A1
反应条件
1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 °C 2.1: trichlorophosphate / 6 h / Reflux 3.1: potassium hydroxide; water / Reflux 3.2: 20 °C 4.1: methanol / tetrahydrofuran / 2 h / 20 °C View Scheme
参考文献
WO2009/155156 A1, ;
WO 2009/155156 A1
反应条件
1.1: trichlorophosphate / 6 h / Reflux 2.1: potassium hydroxide; water / Reflux 2.2: 20 °C 3.1: methanol / tetrahydrofuran / 2 h / 20 °C View Scheme
参考文献
WO2009/155156 A1, ;
WO 2009/155156 A1
反应条件
1.1: potassium hydroxide; water / Reflux 1.2: 20 °C 2.1: methanol / tetrahydrofuran / 2 h / 20 °C View Scheme
参考文献
WO2009/155156 A1, ;
WO 2009/155156 A1
反应条件
1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 4 h / 0 - 20 °C 2: trichlorophosphate / 1,2-dichloro-ethane / 4 h / |Reflux View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 23, # 6 p. 1736 - 1739
反应条件
water; sodium hydroxide in tetrahydrofuran; methanol T=20°C; 3 h;
参考文献
ELI LILLY AND COMPANY; BLANCO-PILLADO, Maria-Jesus; VETMAN, Tatiana Natali; FISHER, Matthew Joseph; KUKLISH, Steven Lee
Patent: WO2014/4230 A1, 2014 ;
Location in patent: Page/Page column 8; 45 ;
