2-溴-6-[2-(4-甲基苯基)-1,3-二氧戊环-2-基]吡啶合成路线 （共 7 条）
反应条件
1: 2.5 g / BuLi / diethyl ether; hexane / 4 h / -50 °C 2: 1.) NaH, 2.) conc. HCl / 1.) DME, 2 h, 2.) ethanol, H2O, steam bath, 10 min 3: 1.) BuLi, 2.) NaOH / 1.) hexane, toluene, 75 deg C, 2 h, 2.) ethanol, steam bath, 10 min View Scheme
参考文献
Findlay; Butz; Coker; et al.
Journal of Pharmaceutical Sciences, 1984 , vol. 73, # 10 p. 1339 - 1344
反应条件
sodium carbonate; toluene-4-sulfonic acid in ethylene glycol; benzene
参考文献
Findlay; John W. A.; Coker; Geoffrey G.
Patent: US4501893 A1, 1985 ;
反应条件
sodium carbonate in ethylene glycol; benzene
参考文献
THE WELLCOME FOUNDATION LIMITED
Patent: EP249950 B1, 1991 ;
反应条件
1: 12.2 g / BuLi / hexane; diethyl ether / 3 h / -50 °C
2: 24.3 g / p-toluenesulfonic acid / toluene / 6 h / Heating
View Scheme
参考文献
Findlay; Butz; Coker; et al.
Journal of Pharmaceutical Sciences, 1984 , vol. 73, # 10 p. 1339 - 1344
反应条件
1: 12.2 g / BuLi / hexane; diethyl ether / 3 h / -50 °C
2: 24.3 g / p-toluenesulfonic acid / toluene / 6 h / Heating
View Scheme
参考文献
Findlay; Butz; Coker; et al.
Journal of Pharmaceutical Sciences, 1984 , vol. 73, # 10 p. 1339 - 1344
反应条件
toluene-4-sulfonic acid in toluene
6 h; Heating;
参考文献
Findlay; Butz; Coker; et al.
Journal of Pharmaceutical Sciences, 1984 , vol. 73, # 10 p. 1339 - 1344
反应条件
1: 2.5 g / BuLi / diethyl ether; hexane / 4 h / -50 °C
2: 1.) NaH, 2.) conc. HCl / 1.) DME, 2 h, 2.) ethanol, H2O, steam bath, 10 min
View Scheme
参考文献
Findlay; Butz; Coker; et al.
Journal of Pharmaceutical Sciences, 1984 , vol. 73, # 10 p. 1339 - 1344
